Clobecort Cream

• Inflammatory skin disorders
• Eczema
• Dermatitis
• Atopic eczema
• Photodermatitis
• Otitis externa
• Primary irritant & allergic dermatitis (napkin rash)
• Prurigo nodularis
• Seborrhoeic dermatitis
• Insect bite reactions

Clobetasone butyrate is classed as a moderately potent topical corticosteroid. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation.

Adult Dose (Topical): Use as 0.05% cream or ointment to be applied thinly once or twice daily on affected areas. Should not be used every day for more than 4 weeks at a time.

Common Side Effects:

• Local atrophic changes (skin thinning)
• Pigmentation changes
• Hypertrichosis (excessive hair growth)
• Increased liability to infection
• Infections may be masked
• Acute adrenal insufficiency
• Growth retardation in children
• Cushingoid symptoms
• Amenorrhoea
• Hyperhidrosis (excessive sweating)

Safety data on clobetasone in pregnant women is not available. Published data report a significantly increased risk of low birthweight with the use of greater than 300 grams of potent or very potent topical corticosteroid during pregnancy. Pregnancy Category C.

• May be absorbed in sufficient amounts to cause systemic effects when applied topically to large areas, broken skin or under occlusive dressings.
• Use with caution in peptic ulcer, osteoporosis, psychoses or severe psychoneuroses.
• Not to be used indiscriminately for pruritus.
• Caution in CHF or hypertension, diabetes mellitus, epilepsy, glaucoma, infectious diseases, ocular herpes simplex, chronic renal failure and uraemia.
• Caution in active or doubtfully quiescent tuberculosis.
• Not for local treatment of eye disorders.
• Avoid prolonged use on the face.
• Caution during pregnancy and lactation.

Acute overdosage is very unlikely to occur. In the case of chronic overdosage or misuse, features of hypercortisolism may appear; topical steroids should be discontinued gradually.

Store in a cool and dry place, away from light and out of reach of children.