oshudhkosh

Clopixol10mg

Rx
Dosage form:
Tablet
Pack size:
Tablet

৳ 15.93/unit

Pack: ৳ 15.93

At a glance

Generic Name: Zuclopenthixol Dosage Form: Tablet, Acuphase Injection, Depot Injection Therapeutic Class: Phenothiazine Related Drugs Pharmacological Class: Typical Antipsychotic (Thioxanthene Derivative) Indications: Used for the management of schizophrenia and acute psychotic episodes associated with schizophrenia. Mechanism of Action: Blocks dopamine D1 and D2 receptors in the brain, helping to reduce psychotic symptoms. Prescription Status: Prescription Only Medicine (POM)

Description

Zuclopenthixol is a prescription antipsychotic medicine primarily used to treat schizophrenia and other psychotic disorders. It works by regulating dopamine activity in the brain, helping reduce hallucinations, delusions, agitation, and disorganised thinking while improving overall mental functioning. This medicine is usually administered as an injection by a qualified healthcare professional and should not be self-administered. It is important to follow your doctor's instructions and complete the prescribed course of treatment without stopping it abruptly. Common side effects may include dizziness, drowsiness, dry mouth, constipation, muscle stiffness, and weight gain. Maintaining a healthy lifestyle, avoiding alcohol, and attending regular medical follow-up can help ensure safe and effective treatmen

Indications

Management of schizophrenia Initial treatment of acute psychotic episodes Exacerbation of psychosis associated with schizophrenia

Therapeutic class

Phenothiazine Related Drugs

Pharmacological class

Typical Antipsychotic (Thioxanthene Derivative)

Pharmacology

Zuclopenthixol has a high affinity for dopamine D1 and D2 receptors and also blocks α1-adrenergic and 5-HT2 receptors, contributing to its antipsychotic effects.

Mechanism of action

Zuclopenthixol has high affinity for D1 and D2 receptors and ?-adrenoreceptors. It also has slight antihistamine properties and blocks serotonergic properties.

Dosage

Blocks dopamine D1 and D2 receptors. Reduces excessive dopamine activity in the brain. Helps control hallucinations, delusions, and psychotic symptoms.

Administration

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Side effects

Common: • Abnormality of voluntary movements • Constipation • Dryness in mouth • Increased prolactin level in blood • Orthostatic hypotension (sudden lowering of blood pressure on standing) • Sleepiness • Tremor • Urinary retention • Weight gain

Precautions & warnings

Zuclopenthixol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Zuclopenthixol is administered into the muscle of the buttock or thigh. Use caution while driving or doing anything that requires concentration as Zuclopenthixol can cause dizziness and sleepiness. Avoid drinking alcohol while taking this medicine because it can make drowsiness worse. It may affect how your body regulates your temperature. Avoid situations that can result in your overheating or getting dehydrated. It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly. Inform your doctor if you experience any swelling, particularly of the face, lips, jaw and tongue and trouble breathing while taking this medicine.

Contraindications

Hypersensitivity. Comatose states e.g. alcohol, barbiturate and opiate intoxications; porphyria. children.

Drug interactions

Zuclopenthixol may enhance the sedative effects of alcohol and the effects of barbiturates and other CNS depressants. Zuclopenthixol reduces the antihypertensive effect of guanethidine. Concomitant use of metoclopramide and piperazine with zuclopenthixol increases the risk of extrapyramidal symptoms. Increased risk of severe neurotoxicity with lithium and sibutramine. Increased anticholinergic side effects with drugs with anticholinergic properties. Potentially Fatal: Antagonises effect of apomorphine, levodopa and other dopamine agonists. Increased risk of blood dyscrasias with clozapine. Increased risk of arrhythmias with dugs that prolong QT interval e.g. class Ia and III antiarrhythmics, erythromycin or cause electrolyte disturbances e.g. thiazide diuretics.

Food interactions

[UNSAFE] Zuclopenthixol may cause excessive drowsiness with alcohol.

Use in pregnancy

[CONSULT YOUR DOCTOR] Zuclopenthixol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[CONSULT YOUR DOCTOR] Zuclopenthixol is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Pediatric use

Safety and efficacy have not been established in children under 18 years of age.

Geriatric use

Elderly patients may require lower doses and closer monitoring.

Renal / hepatic impairment

[CAUTION] Zuclopenthixol should be used with caution in patients with kidney disease. Dose adjustment of Zuclopenthixol may be needed. Please consult your doctor. [CAUTION] Zuclopenthixol should be used with caution in patients with liver disease. Dose adjustment of Zuclopenthixol may be needed. Please consult your doctor.

Overdose effects

Symptoms of overdose may include somnolence, coma, convulsions, shock, abnormal movements, and altered body temperature.

Storage conditions

Store between 15°C and 25°C, protect from light, and keep out of the reach of children.

Chemical structure

Common Name: Zuclopenthixol IUPAC Name: (Z)-2-[4-[3-(2-Chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol Molecular Formula: C₂₂H₂₅ClN₂OS Molecular Weight: 400.96 g/mol

Common questions

Question: What is Zuclopenthixol? Answer: Zuclopenthixol is a typical antipsychotic medicine primarily used for the treatment of schizophrenia. Question: What is Zuclopenthixol used for? Answer: It is used to manage symptoms of schizophrenia and for the initial treatment of acute psychotic episodes. Question: How should Zuclopenthixol be taken? Answer: The dosage of tablets or injections depends on the patient's condition. It should only be used according to the instructions of a healthcare professional. Question: What are the common side effects of Zuclopenthixol? Answer: Common side effects include tremor, increased heart rate (tachycardia), palpitations, muscle stiffness (hypertonia), and dystonia. Question: Can alcohol be consumed while taking Zuclopenthixol? Answer: No. Alcohol may increase the sedative effects and central nervous system effects of Zuclopenthixol. Alcohol should be avoided during treatment. Question: Can Zuclopenthixol be used during pregnancy? Answer: The safety of Zuclopenthixol during pregnancy has not been established. It should only be used during pregnancy under the advice of a healthcare professional. Question: Can Zuclopenthixol be used during breastfeeding? Answer: Zuclopenthixol may pass into breast milk. Consult a healthcare professional before using it during breastfeeding. Question: How should Zuclopenthixol be stored? Answer: Store between 15°C and 25°C, protect from light, and keep out of the reach of children.

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.