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At a glance

Generic Name: Zuclopenthixol Dosage Form: Tablet, Acuphase Injection, Depot Injection Therapeutic Class: Phenothiazine Related Drugs Pharmacological Class: Typical Antipsychotic (Thioxanthene Derivative) Indications: Used for the management of schizophrenia and acute psychotic episodes associated with schizophrenia. Mechanism of Action: Blocks dopamine D1 and D2 receptors in the brain, helping to reduce psychotic symptoms. Prescription Status: Prescription Only Medicine (POM)

Indications

Management of schizophrenia Initial treatment of acute psychotic episodes Exacerbation of psychosis associated with schizophrenia

Pharmacology

Zuclopenthixol has a high affinity for dopamine D1 and D2 receptors and also blocks α1-adrenergic and 5-HT2 receptors, contributing to its antipsychotic effects.

Dosage

Blocks dopamine D1 and D2 receptors. Reduces excessive dopamine activity in the brain. Helps control hallucinations, delusions, and psychotic symptoms.

Side effects

Common: • Abnormality of voluntary movements • Constipation • Dryness in mouth • Increased prolactin level in blood • Orthostatic hypotension (sudden lowering of blood pressure on standing) • Sleepiness • Tremor • Urinary retention • Weight gain

Use in pregnancy

[CONSULT YOUR DOCTOR] Zuclopenthixol may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Precautions & warnings

Zuclopenthixol may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Zuclopenthixol is administered into the muscle of the buttock or thigh. Use caution while driving or doing anything that requires concentration as Zuclopenthixol can cause dizziness and sleepiness. Avoid drinking alcohol while taking this medicine because it can make drowsiness worse. It may affect how your body regulates your temperature. Avoid situations that can result in your overheating or getting dehydrated. It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly. Inform your doctor if you experience any swelling, particularly of the face, lips, jaw and tongue and trouble breathing while taking this medicine.

Overdose effects

Symptoms of overdose may include somnolence, coma, convulsions, shock, abnormal movements, and altered body temperature.

Storage conditions

Store between 15°C and 25°C, protect from light, and keep out of the reach of children.

Zuclopenthixol — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.