৳ 5.85/unit
Pack: ৳ 5.85
৳ 5.85/unit
Pack: ৳ 5.85
At a glance
Cloxacillin is a narrow-spectrum penicillin antibiotic used for the treatment of gram-positive bacterial infections, particularly those caused by penicillinase-producing staphylococci.
Indications
- Skin and soft tissue infections (boils, abscess, carbuncle, cellulitis, infected wounds, infected burns)
- Respiratory tract, ear, nose and throat infections (pneumonia, lung abscess, sinusitis, pharyngitis, tonsillitis, otitis media)
- Osteomyelitis
- Enteritis
- Endocarditis
- Urinary tract infections
- Septicemia
Pharmacology
Cloxacillin is a narrow-spectrum penicillin effective against gram-positive bacteria. It is resistant to the penicillinase enzyme which inactivates other penicillins. Cloxacillin kills bacteria by interfering with bacterial cell wall synthesis. It binds to penicillin-binding proteins, inhibiting the final transpeptidation step of peptidoglycan synthesis, leading to cell wall weakening and bacterial lysis.
Dosage
Adult Dose (Oral): 250-500 mg 4 times daily (half to one hour before meals).
Adult Dose (Parenteral - IM/IV): 1-2 g every 6 hours; severe infections (meningitis, endocarditis): 2 g every 4 hours.
Pediatric Dose (Oral): 50-100 mg/kg/day in divided doses every 6 hours.
Pediatric Dose (Oral - 2-10 years): Half of adult dose; <2 years: Quarter of adult dose.
Pediatric Dose (Parenteral - IM): 250 mg (with 1.5 mL WFI) or 500 mg (with 2 mL WFI).
Side effects
Common Side Effects:
- Rash
- Vomiting
- Allergic reaction
- Nausea
- Diarrhea
- Fever
- Indigestion
Use in pregnancy
[SAFE IF PRESCRIBED] Cloxacillin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [SAFE] Cloxacillin does not usually affect your ability to drive.
- You have been prescribed Cloxacillin for the treatment of bacterial infections. Finish the prescribed course, even if you start to feel better.
- Take it with food and plenty of fluids to avoid an upset stomach.
- Diarrhea may occur as a side effect but should stop when your course is complete.
- Inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking this medicine.
- Use with caution in patients with a history of allergy.
Overdose effects
Cloxacillin overdose symptoms include nausea, vomiting, diarrhea, and seizures (especially in renal impairment). Treatment is symptomatic and supportive.
Storage conditions
Store in a cool and dry place. Store injection vials below 25°C. Reconstituted suspension should be used within 5 days at room temperature or 7 days in the refrigerator.