৳ 66.20/unit
Pack: ৳ 926.80
৳ 66.20/unit
Pack: ৳ 926.80
At a glance
Hydrochlorothiazide + Valsartan combination is used for the treatment of hypertension.
Indications
- Hypertension (high blood pressure)
Pharmacology
Valsartan is an oral medication that belongs to a class of drugs called angiotensin receptor blockers (ARBs). It is orally active and specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin's attachment to the receptors cause the blood vessels to narrow (vasoconstrict) which leads to an increase in blood pressure (hypertension). Valsartan blocks the angiotensin II receptor. By blocking the action of angiotensin, Valsartan dilates blood vessels and reduces blood pressure without affecting pulse rate. Valsartan has much greater affinity (about 20,000-fold) for the AT1 receptor than for the AT2 receptor. Hydrochlorothiazide inhibits Na+/Cl- reabsorption in the distal convoluted tubule, increasing sodium and chloride excretion, which reduces plasma volume and activates the renin-aldosterone system.
Dosage
Adult Dose (Oral):
- Initial: 1 tablet/day (80-160 mg valsartan + 12.5-25 mg HCTZ)
- May titrate after 1-2 weeks if needed
- Max: Valsartan 320 mg + HCTZ 25 mg daily
Elderly: No initial dosage adjustment necessary
Renal Dose: CrCl <30 mL/min: Not recommended
Side effects
Common Side Effects:
- Headache
- Dizziness
- Fatigue
- Abdominal pain
- Cough
- Diarrhea
- Nausea
- Hyperkalemia
- Reduced renal function
- Hypotension
Others: Impotence, allergic reactions, dyspnea, constipation, back pain, muscle cramps, rash, anxiety, insomnia, vertigo
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; in 2nd and 3rd trimester can cause injury or death to fetus; discontinue when pregnancy is detected.
Precautions & warnings
Precautions:
- Hydrochlorothiazide + Valsartan may decrease alertness, affect vision or make you feel sleepy and dizzy; do not drive if these symptoms occur
- May cause dehydration; drink plenty of fluids; inform doctor if extreme thirst, very dry mouth or muscle weakness develops
- May cause dizziness; get up slowly when rising from a sitting or lying position
- Not safe during pregnancy and breastfeeding
- Hepatic Impairment: As majority of valsartan is eliminated in bile, caution in mild to moderate hepatic impairment
- Renal Impairment: Dosage reduction or discontinuation may be required with pre-existing renal impairment
- Caution in heart failure and post-myocardial infarction patients
Overdose effects
Overdose: Valsartan: Hypotension and tachycardia; bradycardia may occur; if excessive hypotension occurs, place in supine position and give IV normal saline. Hydrochlorothiazide: Electrolyte depletion (hypokalemia, hypochloremia) and dehydration; hypokalemia with digitalis may accentuate cardiac arrhythmias; symptomatic treatment.
Storage conditions
Store between 15-30°C.