Colimax

• Treatment of acute gout flares
• Prophylaxis of gout (intercritical periods)
• Prevention of gout attacks during surgery
• Familial Mediterranean Fever (FMF) - patients 4 years and older

An acute attack of gout apparently occurs as a result of an inflammatory reaction to crystals of monosodium urate that are deposited in the joint tissue from hyperuric body fluids; the reaction is aggravated as more urate crystals accumulate. Leukocytes migrate to the sites where urate crystals have been deposited and try to engulf the crystals by phagocytosis. As a result lactic acid and proinflammatory enzymes are released which cause inflammation with severe pain, redness, and swelling of the affected joint. Lactic acid favors a local decrease in pH that enhances uric acid deposition. Colchicine inhibits the phagocytosis of uric acid by leukocytes & also diminishes the lactic acid production directly. Thus interrupts the cycle of urate crystal deposition and inflammatory response that sustains the acute attack of gout.

Acute Gout Flare (Adult): 1.2 mg at first sign, then 0.6 mg 1 hour later; not to exceed 1.8 mg in 1 hour. Alternative: 1-1.2 mg first dose, then 0.6 mg every 2 hours until pain and inflammation subside.

Gout Prophylaxis (Adult): 0.6 mg once daily or every 12 hours; not to exceed 1.2 mg/day.

FMF (Adult): 1.2-2.4 mg/day (single dose or divided every 12 hours); increase by 0.3 mg/day as needed; max 2.4 mg/day.

Pediatric Dose (FMF - 12 years): 1.2-2.4 mg/day.

Surgical Prophylaxis: 0.6 mg three times daily for 3 days before and 3 days after surgery.

Common Side Effects:

• Nausea
• Vomiting
• Abdominal pain
• Diarrhea
• Pharyngolaryngeal pain

Serious Side Effects: Myelosuppression, leukopenia, granulocytopenia, thrombocytopenia, aplastic anemia.

[CONSULT YOUR DOCTOR] Colchicine may be unsafe to use during pregnancy. Pregnancy Category C.

• [UNSAFE] Colchicine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
• Inform your doctor if you have serious nausea, vomiting, diarrhea, or tingling in your fingers or toes.
• It can lower your body's ability to make new blood cells. Inform your doctor if you have frequent bleeding, bruising, fevers, or if you are always tired.
• Do not take Colchicine if you have severe liver disease, kidney disease, or if you are pregnant or breastfeeding.

The exact dose that produces significant toxicity is unknown. Ingestion of less than 0.5 mg/kg typically results in milder toxicities (gastrointestinal symptoms), while 0.5-0.8 mg/kg may cause severe reactions (myelosuppression).

Store below 30°C temperature. Protect from light and moisture. Keep out of reach of children.