৳ 2.75/unit
Pack: ৳ 82.50
৳ 2.75/unit
Pack: ৳ 82.50
At a glance
Entacapone is a prescription medicine used in the treatment of Parkinson's disease. It works in combination with carbidopa/levodopa and helps control abnormal body movements.
Indications
- Parkinson's Disease: Used in combination with levodopa for the treatment of Parkinson's disease, particularly for "end-of-dose" motor fluctuations.
Pharmacology
Entacapone is a selective, reversible, peripheral inhibitor of COMT, an enzyme involved in the metabolism of dopamine and levodopa. It is used in patients with Parkinson's disease and "end-of-dose" motor fluctuations that cannot be stabilised on levodopa combinations alone.
Dosage
Adult Dose:
- Parkinson's Disease (with levodopa): 200 mg with each levodopa/dopa decarboxylase inhibitor dose. Max: 200 mg 10 times daily (2,000 mg daily).
- Hepatic Impairment: Safety and efficacy not established.
Renal Dose: No dose adjustment necessary in renal impairment.
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Fatigue
- Confusion
- Constipation
- Insomnia (difficulty in sleeping)
- Nightmares
- Hallucination
- Increased sweating
- Fall
- Urine discoloration
- Dizziness
- Diarrhea
- Muscle coordination impaired
- Ischemic heart disease
- Heart attack
- Abdominal pain
- Dryness in mouth
Use in pregnancy
Use in Pregnancy: Entacapone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Entacapone may cause dizziness or weakness due to low blood pressure. Do not drive if these symptoms occur.
- It can make you very sleepy. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Inform your doctor if you develop impulsive, unusual behavior and/or an abnormally high sex drive.
- Talk to your doctor in case you develop hallucinations or other changes in your behavior.
- It is common to have diarrhea with this drug. Therefore, drink plenty of fluids and watch for weight loss.
- Do not get worried if you notice a reddish-brown discoloration in your urine as it is harmless in nature.
- Do not stop taking the medication suddenly without talking to your doctor.
Overdose effects
Overdose: Limited information is available on overdose. In case of overdose, symptomatic treatment should be given and seek immediate medical attention.
Storage conditions
Storage: Store in a cool and dry place, protected from light and moisture. Store below 30°C. Keep out of reach of children.