osudhkosh
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Company•Beacon Pharmaceuticals PLC

Criston 1

Rx
Generic: Vincristine Sulphate

৳ 1/unit

Pack: ৳ 1

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At a glance

Vincristine Sulphate is an anti-cancer medication used in the treatment of breast cancer, non-small cell lung cancer, pancreatic cancer, kidney cancer, blood cancer, multiple myeloma, lymphomas and bone cancer.

Indications
  • Breast cancer
  • Non-small cell lung cancer
  • Pancreatic cancer
  • Kidney cancer
  • Blood cancer
  • Multiple myeloma
  • Lymphomas
  • Bone cancer
  • Acute leukemia
  • Hodgkin's disease
  • Non-Hodgkin's malignant lymphomas
  • Rhabdomyosarcoma
  • Neuroblastoma
  • Wilms' tumor
Pharmacology

Vincristine arrests cell division at the metaphase stage by inhibiting microtubule formation in the mitotic spindle.

Dosage

Adult Dose (IV):

  • Acute lymphoblastic leukaemia: 1.4-1.5 mg/m² once weekly; max 2 mg weekly
  • Hepatic impairment: If serum bilirubin >3 mg/100ml, reduce dose by 50%

Child Dose (IV):

  • Acute lymphoblastic leukaemia: 1.5-2 mg/m² once weekly; for patients ≤10 kg: initiate at 0.05 mg/kg once weekly

Renal Impairment: Dose adjustment not necessary

Side effects

Common Side Effects:

  • Hair loss
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Constipation
  • Nausea
  • Vomiting
  • Diarrhea
  • Decreased appetite
  • Decreased white blood cell count
  • Stomatitis
  • Neurotoxicity
Use in pregnancy

Use in Pregnancy: Unsafe; definite evidence of risk to the developing baby; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect ability to drive
  • Avoid being near people suffering from infections; leukopenia possible
  • Avoid even accidental contamination of eyes
  • May cause acute kidney disease related to uric acid level
  • Elderly are more susceptible to neurotoxic effects
  • May cause aspermia (infertility) in males; amenorrhea in females
  • Consult doctor if pregnant or breastfeeding
Overdose effects

Symptoms: Neurotoxicity, bone marrow suppression, extravasation.

Treatment: Supportive care.

Storage conditions

Store in a refrigerator at 2°C - 8°C. Do not freeze. Protect from light. Keep out of the reach of children.

Vincristine Sulphate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.