Cybine 500

• Acute Myeloid Leukemia (AML)
• Acute Lymphocytic Leukemia (ALL)
• Chronic Myeloid Leukemia (CML)
• Erythroleukemia
• Meningeal Leukemia
• Non-Hodgkin's Lymphoma (children)

Adult - Acute Nonlymphocytic Leukemia (Induction): 100-200 mg/sq.meter/day IV for 5-10 days; OR 100 mg/sq.meter IV every 12 hours for 7 days.

Adult - Meningeal Leukemia (Intrathecal): 5-75 mg/sq.meter every 2-7 days until CNS findings normalize.

Adult - Refractory Leukemia: 3 g/sq.meter IV (infusion over 1-3 hours) every 12 hours x 4-12 doses; repeat every 2-3 weeks.

Adult - Meningeal Leukemia (IT): 30 mg/sq.meter intrathecal every 4 days until CSF findings normal plus one additional dose.

Common Side Effects:

• Rash
• Skin ulcer
• Nausea
• Vomiting
• Hair loss
• Abdominal pain
• Anal ulcers
• Anemia
• Decreased white blood cell count
• Fever
• Infection
• Abnormal liver function
• Low blood platelets
• Mouth ulcer
• Pneumonia
• Sepsis
• Mouth sore
• Stomatitis

Serious Side Effects:

• Myelosuppression (leukopenia, thrombocytopenia, anemia)
• Cytarabine syndrome (fever, myalgia, bone pain, rash, conjunctivitis)
• Neurotoxicity (with intrathecal use)
• Anaphylactoid reactions
• Flu-like syndrome

• May affect your ability to drive.
• Use a reliable contraceptive method to prevent pregnancy while taking this medicine.
• Inform your doctor immediately if you notice any signs of infection such as fever, sore throat, rash or severe diarrhea.
• Regular blood tests are required to check blood cells, heart, liver, and uric acid levels.
• Patients with previous drug-induced bone marrow suppression should use with caution.