Cyclotox200mg/vial

Cyclophosphamide is used in the treatment of different kinds of cancers. It is also used to treat kidney disease known as nephrotic syndrome in children after other treatments have not worked. It may be also used to treat other conditions, as determined by the doctor. Cyclophosphamide should be taken with food preferably in morning but at the same time every day to get the most benefit. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include vomiting, nausea, hair loss, fever, and blood in urine. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects. It is very strong medicine and some people may develop serious side effects while taking it. This medicine may lower your ability to fight infections and lead to problems with your blood, liver or kidneys. Your doctor will advise you regular blood tests to check for these. It is advised that you drink extra fluids so that you pass more urine. This will help prevent bladder and kidney problems and keep your kidneys working well. Before taking it, tell your doctor if you have liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Cyclophosphamide is an anti-cancer medication. It is an alkylating agent which works by damaging the genetic material (DNA and RNA) of the cancer cells, thereby stopping their growth and multiplication. This is how it works against cancer.

• Cancer • Nephrotic syndrome

Cyclophosphamide is a prodrug which is converted in the body to the active metabolites. It acts at any stage of the cell cycle but its main action is blockage at the G2 stage. It arrests cell division by alkylating the DNA in a dose-dependent manner. It also exerts immunosuppressive effects possibly due to a cytotoxic effect on lymphocytes.

Adult Dose: Malignant Diseases IV (intermittent therapy): 40-50 mg/kg (400-1800 mg/m²) divided over 2-5 days; may be repeated at intervals of 2-4 weeks IV (continuous daily therapy): 60-120 mg/m²/day (1-2.5 mg/kg/day) PO (intermittent therapy): 400-1000 mg/m² divided over 4-5 days PO (continuous daily therapy): 50-100 mg/m²/day or 1-5 mg/kg/day Nephrotic Syndrome 2-3 mg/kg/day for up to 12 weeks when corticosteroids unsuccessful Non-Hodgkin Lymphoma 600-1500 mg/m² IV with other antineoplastics (part of CHOP regimen); dose intensification possible Breast Cancer 600 mg/m² IV with other antineoplastics; dose intensification possible Child Dose: Malignant Diseases IV (intermittent therapy): 40-50 mg/kg (400-1800 mg/m²) divided over 2-5 days; may be repeated at intervals of 2-4 weeks IV (continuous daily therapy): 60-120 mg/m²/day (1-2.5 mg/kg/day) PO (intermittent therapy): 400-1000 mg/m² divided over 4-5 days PO (continuous daily therapy): 50-100 mg/m²/day uvenile Idiopathic Arthritis/Vasculitis 10 mg/kg IV every 2 weeks Nephrotic Syndrome 2-3 mg/kg/day for up to 12 weeks when corticosteroids unsuccessful Systemic Lupus Erythematosus 500-750 mg/m² IV monthly; not to exceed 1 g/m²

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Cyclophosphamide is to be taken with food.

Common: • Vomiting • Nausea • Hair loss • Fever • Blood in urine • Diarrhea • Decreased white blood cell count (neutrophils)

[UNSAFE] Cyclophosphamide may cause side effects which could affect your ability to drive. Cyclophosphamide may cause undesirable effects (e.g., dizziness, blurred vision, visual impairment) which could affect the ability to drive. Cyclophosphamide helps in the treatment of cancer. Drink plenty of fluids or urinate frequently to prevent urinary problems while taking this medication. Take it with food if you experience irritation of the stomach, preferably in the morning. Your doctor may get regular blood tests to monitor your blood counts while on treatment with this medication. You are more likely to get sick or heal slower while taking this medication. Talk to your doctor before getting any vaccines. Contact your doctor immediately if you experience difficulty in urinating or blood in urine while on treatment with this medication. Do not take Cyclophosphamide if you are pregnant or breastfeeding. Use effective contraception method to prevent pregnancy while taking this medicine.

Bladder haemorrhage. Patients with bone-marrow aplasia, acute infection, drug- or radiation-induced urothelial toxicity. Porphyria. Pregnancy and lactation.

Increased risk of cardiotoxicity w/ doxorubicin or other cardiotoxic drugs. May increase incidence of mucositis w/ protease inhibitors. May increase haematotoxicity and/or immunosuppression w/ ACE inhibitors, natalizumab, paclitaxel, thiazide diuretics, zidovudine. May increase pulmonary toxicity w/ amiodarone. May increase nephrotoxicity w/ amphotericin B. May result to acute water intoxication w/ indometacin. May increase risk of hepatotoxicity w/ azathioprine. May increase incidence of hepatic veno-occlusive disease and mucositis w/ busulfan. May increase risk of haemorrhagic cystitis w/ previous or concomitant radiotherapy. May result to acute encephalopathy w/ metronidazole. May increase risk of thromboembolic complications. May alter the effect of warfarin. May increase immunosuppressive effect of ciclosporin. May result to prolonged apnoea w/ depolarising muscle relaxants (e.g. suxamethonium).

[UNSAFE] It is unsafe to consume alcohol with Cyclophosphamide.

[CONSULT YOUR DOCTOR] Cyclophosphamide is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Cyclophosphamide is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Cyclophosphamide should be used with caution in patients with severe kidney disease. Dose adjustment of Cyclophosphamide may be needed. Please consult your doctor. [CAUTION] Cyclophosphamide should be used with caution in patients with liver disease. Dose adjustment of Cyclophosphamide may be needed. Please consult your doctor.

I have pausi immune vasculitis syndrome p-anca negative .with multple organ disorder. I used allopathy medicines wysolne and endoxan now . is there any better treatment in ayurveda for my condition. Hi Kindly consult to your nearest ayurvedic doctor face to face consultation . Nephrotic syndrome since December 2009 Show to kidney Sir I have pausi immune vasculitis syndrome p-anca negative .with multple organ disorder. I used allopathy medicines wysolne and endoxan now . is there any better treatment in homeo for my condition sir ok. Please tell me your all symptoms in detail and also send me if you have reports. nephrotic syndrome protein in urine Hi Kindly consult to your nearest Ayurvedic doctor Need to take proper treatment STAGE 3 Non hodkins lyphoma follicular Current Medicine as below Endoxan P Carzine 50 mg Omnacortil 5 Pentosec-d Whr u r getting treatmentGenerally p carzine is not given in this lymphomaHowever if disease comes back after treatmentIt can be given Nephrotic syndrome ,started two years back,two time relapse. Ok attach all reports in my whatup no 9XXXXXX She is a patient of Vasculitis effecting kidney. Undergone 6 cycles of endoxan. Pl suggest the best option available. Her creatinine level is 2.6 Please post your query in Physician or Cardiologist section