৳ 40/unit
Pack: ৳ 400
৳ 40/unit
Pack: ৳ 400
At a glance
Pentosan Polysulfate Sodium is used for the relief of bladder pain or discomfort associated with interstitial cystitis. It is a polymer of xylose hydrogen sulfate that binds Fibroblast growth factors (FGFs) and other heparin-binding growth factors.
Indications
- Bladder pain or discomfort associated with interstitial cystitis
Pharmacology
Pentosan Polysulfate Sodium is a heparin-like polymer that binds Fibroblast growth factors (FGFs) and other heparin-binding growth factors. It forms a protective layer on the bladder wall and reduces inflammation.
Dosage
Adult Dose (Oral):
- Recommended dose: 300 mg/day (100 mg capsule three times daily)
- Take with water at least 1 hour before or 2 hours after meals
- Reassess after 3 months; may continue for another 3 months if no improvement
- Clinical value of continued treatment beyond 6 months in non-responders is unknown
Pediatric Dose: Safety and efficacy not established in children under 16 years.
Side effects
Side Effects:
- Rectal hemorrhage (6.3% of patients at 300 mg/day)
- Ecchymosis
- Epistaxis
- Gum hemorrhage
- Alopecia (97% alopecia areata; begins within first 4 weeks of treatment)
- Elevated liver enzymes (at higher doses)
Use in pregnancy
Use in Pregnancy: Animal studies showed no evidence of impaired fertility or fetal harm; however, adequate human studies not available; use only if clearly needed.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Weak anticoagulant (1/15 activity of heparin)
- Evaluate patients undergoing invasive procedures or with underlying coagulopathy or increased bleeding risk
- Caution in patients with aneurysms, thrombocytopenia, hemophilia, GI ulcerations, polyps, or diverticula
- Caution in history of heparin-induced thrombocytopenia
- Similar product given subcutaneously/sublingually/IM is associated with delayed immunoallergic thrombocytopenia
Overdose effects
Overdose has not been reported; toxicity may manifest as anticoagulation, bleeding, thrombocytopenia, liver function abnormalities, and gastric distress. In acute overdose, gastric lavage and symptomatic/supportive treatment.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.