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At a glance

Misoprostol is a medicine used for medical abortion and prevention of postpartum hemorrhage.

Indications
  • Medical abortion
  • Prevention and treatment of postpartum hemorrhage
  • Induction of labor
  • NSAID-induced gastric and duodenal ulcers
Pharmacology

Misoprostol is a synthetic prostaglandin E1 analogue that binds to prostaglandin receptors causing uterine smooth muscle contraction.

Dosage

Adult Dose:

  • Abortion: 800 mcg buccally 24-48 hours after 200 mg Mifepristone
  • Postpartum hemorrhage prevention: 600 mcg orally immediately after delivery
  • Induction of labor: 25 mcg vaginally (every 6 hours)
  • NSAID-induced ulcer: 200 mcg 2-4 times daily
Side effects

Common Side Effects:

  • Nausea and vomiting
  • Uterine contractions and cramping
  • Diarrhea
  • Vaginal bleeding
  • Abdominal pain
Use in pregnancy

Use in Pregnancy: Highly unsafe. Contraindicated during pregnancy.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution while driving
  • Contraindicated in pregnancy
  • Caution during lactation
  • Do not use if history of prostaglandin allergy
Overdose effects

Overdose may cause sedation tremor convulsions dyspnea abdominal pain diarrhea fever.

Storage conditions

Store in a cool and dry place protected from light and moisture. Keep out of reach of children.

Misoprostol — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.