৳ 3/unit
Pack: ৳ 30
৳ 3/unit
Pack: ৳ 30
At a glance
Pizotifen is a serotonin antagonist used for prophylactic treatment of vascular headache of migraine type, including classical migraine, common migraine, and cluster headache. It is not effective in relieving migraine attacks once in progress.
Indications
- Classical migraine
- Common migraine
- Cluster headache (prophylaxis)
Pharmacology
Pizotifen inhibits peripheral actions of serotonin and histamine, reducing cranial vessel membrane permeability and plasmakinin transudation, and alters pain thresholds in migraines. It blocks 5-HT receptors, attenuating serotonin-induced cranial vasoconstriction and serotonin-enhanced platelet function and aggregation. It also inhibits peripheral actions of bradykinin.
Dosage
Adult Dose (Oral):
- Initial: 0.5 mg; gradually increase as needed
- Maintenance: 1.5 mg daily (single night dose or in 3 divided doses)
- Max: 4.5 mg daily (max 3 mg/dose)
- Hepatic impairment: Dose adjustment may be needed
Pediatric Dose (>2 years):
- Initial: 0.5 mg
- May increase gradually up to 1.5 mg daily in divided doses (max 1 mg/dose)
Side effects
Common Side Effects:
- Drowsiness
- Dry mouth
- Increased appetite
- Weight gain
- Dizziness
- Nausea
Use in pregnancy
Use in Pregnancy: Limited information; no ill effects reported; use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive if drowsy or dizzy
- May cause sleepiness initially; do not drive until you know how it affects you
- May cause weight gain; eat a balanced diet, avoid high-calorie snacking, exercise regularly
- Inform doctor if skin rash, muscle aches, tremors, difficulty moving
- Avoid alcohol (increased sedation)
- Long-term use: monitor liver function and vision
Overdose effects
No overdose information available; consult your doctor if taken in excess.
Storage conditions
Store in a dry place, away from light and heat; keep out of reach of children.