Daconib 45
Rx- Generic:
- Dacomitinib
- Company:
- Everest Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Box (30 Tablet)
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৳ 300/unit
Pack: ৳ 9,000
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At a glance
Dacomitinib is an irreversible kinase inhibitor used for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) with EGFR exon 19 deletion or exon 21 L858R substitution mutations.
Indications
- Metastatic non-small cell lung cancer (NSCLC) with EGFR exon 19 deletion or exon 21 L858R substitution mutations
Dosage
Adult: 45 mg orally once daily, continue until disease progression or unacceptable toxicity occurs.
First dose reduction: 30 mg (once daily)
Second dose reduction: 15 mg (once daily)
Side effects
Common Side Effects (Incidence >20%):
- Diarrhea (87%)
- Rash (69%)
- Paronychia (64%)
- Stomatitis (45%)
- Anemia (44%)
- Hypoalbuminemia (44%)
- Lymphopenia (42%)
- Increased ALT (40%)
- Hyperglycemia (36%)
- Increased AST (35%)
- Hypocalcemia (33%)
- Decreased appetite (31%)
- Dry skin (30%)
- Hypokalemia (29%)
- Decreased weight (26%)
- Hyponatremia (26%)
- Increased creatinine (24%)
- Alopecia (23%)
- Increased alkaline phosphatase (22%)
- Hypomagnesemia (22%)
- Pruritus (21%)
- Cough (21%)
- Nasal mucosal disorder (19%)
- Conjunctivitis (19%)
- Nausea (19%)
- Hyperbilirubinemia (16%)
- Palmar-plantar erythrodysesthesia syndrome (15%)
- Pain in extremity (14%)
- Dyspnea (13%)
- Constipation (13%)
- Asthenia (13%)
- Mouth ulceration (12%)
- Musculoskeletal pain (12%)
- Upper respiratory tract infection (12%)
- Dermatitis (11%)
- Insomnia (11%)
Serious Side Effects:
- Interstitial Lung Disease (ILD)/Pneumonitis
- Severe diarrhea
Precautions & warnings
- Severe and fatal ILD/pneumonitis occurred; monitor for pulmonary symptoms indicative of ILD/pneumonitis. Permanently discontinue if ILD is confirmed.
- Severe and fatal diarrhea occurred; promptly initiate antidiarrheal treatment.
- Withhold and reduce dose based on severity of diarrhea and dermatologic reactions.
- Advise females of reproductive potential to use effective contraception.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.