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At a glance
Dapsone is an anti-leprotic and anti-inflammatory medication used for the treatment of leprosy and acne vulgaris.
Indications
- Leprosy
- Acne vulgaris (patients 12 years and older)
- Dermatitis herpetiformis
Dosage
Adult - Leprosy: 100 mg once daily (in combination with other antileprosy drugs).
Adult - Dermatitis Herpetiformis: 50 mg once daily, titrate up to 300 mg daily as needed.
Child: 2 mg/kg (max 100 mg/day) or 4 mg/kg (max 200 mg) once weekly.
Topical Gel (Acne): 7.5% gel once daily or 5% gel twice daily, apply a thin layer (pea-sized amount) to clean, dry skin.
Side effects
Common (Topical): Oiliness/peeling, dryness, and erythema at the application site.
Common (Oral): Rash, fever.
Serious: Methemoglobinemia, hemolysis (in G6PD deficient patients), agranulocytosis, hepatitis.
Precautions & warnings
Discontinue if signs of methemoglobinemia occur; risk of hemolysis in G6PD deficient patients; monitor blood cell counts with long-term use; caution in patients with sulfa hypersensitivity.