৳ 15/unit
Pack: ৳ 150
৳ 15/unit
Pack: ৳ 150
At a glance
Dantrolene Sodium is a centrally acting skeletal muscle relaxant used to control clinical spasticity resulting from spinal cord injury, stroke, cerebral palsy, and multiple sclerosis.
Indications
- Chronic spasticity (spinal cord injury, stroke, cerebral palsy, multiple sclerosis)
- Prevention and treatment of malignant hyperthermia
Pharmacology
Dantrolene produces relaxation by affecting the contractile response of the skeletal muscle at a site beyond the myoneural junction, directly on the muscle itself. In skeletal muscle, Dantrolene dissociates the excitation-contraction coupling, probably by interfering with the release of Ca++ from the sarcoplasmic reticulum.
Dosage
Adult - Chronic Spasticity: Initially, 25 mg twice daily, gradually increased by 25-50 mg/day per week. Maximum: 400 mg/day. Discontinue if no response after 45 days.
Child - Chronic Spasticity: Initially, 0.5 mg/kg once daily for 7 days, then gradually increased to 2 mg/kg 3-4 times daily. Maximum: 100 mg 4 times daily.
Malignant Hyperthermia (Preoperative): 4-8 mg/kg/day in 3-4 divided doses for 1-2 days prior to surgery, with last dose given 3-4 hours before scheduled surgery.
Side effects
Common: Drowsiness, dizziness, muscle weakness/pain, fatigue, diarrhea, GI disturbances, CNS effects, tachycardia, unstable BP, dyspnoea, rashes, pruritus, fever, visual disturbances, dysphagia, speech disturbances, haematuria.
Serious: Hepatotoxicity, aplastic anemia, leukopenia, thrombocytopenia, pleural effusion with pericarditis.
Use in pregnancy
Pregnancy Category C. Dantrolene should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Perform LFTs before and during treatment.
- Increased risk of liver injury in patients >30 years, especially those on estrogen therapy, history of liver disease, or daily dose >400 mg.
- Avoid driving or hazardous occupations (drowsiness, dizziness may occur).
- If diarrhea is severe, temporarily withdraw Dantrolene. If diarrhea recurs on readministration, withdraw permanently.
- Discontinue if no benefit is evident within 45 days.
Overdose effects
Overdose may lead to muscle weakness, drowsiness, diarrhea, and liver toxicity. Seek medical attention.
Storage conditions
Store in a cool & dry place, protected from light. Keep out of reach of children.