Depnox SR150mg
Rx- Generic:
- Bupropion Hydrochloride
- Company:
- Jayson Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Tablet
৳ 10.10/unit
Pack: ৳ 10.10
Price comparison
- This brand
- ৳ 10.1
- Cheapest of this genericZybex SR
- ৳ 10
The cheaper brand costs ৳ 0.10 less per unit
Compared against 2 brands
At a glance
Bupropion Hydrochloride is an atypical antidepressant used in the treatment of depression and smoking addiction. It works by increasing the levels of neurotransmitters (dopamine and norepinephrine) in the brain.
Indications
- Depression
- Smoking cessation
Dosage
Adults (Depression - Immediate-release): Initially 100 mg twice daily; if needed, increase to 100 mg three times daily after 3 days; further increase to 150 mg three times daily if no improvement after several weeks. Max: 150 mg three times daily.
Adults (Depression - Modified-release/Sustained-release): Initially 150 mg once daily in the morning; if needed, increase to 150 mg twice daily after 3 days; further increase to 200 mg twice daily if needed after several weeks. Max: 450 mg/day (as a single dose).
Adults (Smoking cessation - Modified-release): Initially 150 mg once daily for 6 days, then 150 mg twice daily. Treatment duration: 7-12 weeks. Discontinue if abstinence not achieved by week 7. Max: 300 mg/day.
Elderly (Depression - Immediate-release): Initially 37.5 mg twice daily.
Elderly (Depression - Sustained-release): Initially 100 mg/day; increase by 37.5-100 mg every 3-4 days. Max: 300 mg/day in divided doses.
Hepatic impairment: Mild-moderate: Reduce dose or dosing frequency. Severe (immediate-release): Max 75 mg once daily; (modified-release): Max 100 mg once daily or 150 mg every other day.
Renal impairment: Caution; consider dose reduction.
Children and adolescents (under 18 years): Not recommended.
Side effects
Common side effects: Insomnia, allergic reaction, impaired concentration, sweating, headache, nausea, vomiting, dizziness, dry mouth, taste change, abdominal pain, agitation, anxiety, fever, constipation, tremor.
Hypersensitivity reactions: Pruritus, urticaria, angioedema, dyspnea, anaphylactoid reactions (rare).
Serious (rare): Seizures (dose-dependent; higher risk with history of seizures, bulimia/anorexia, abrupt alcohol/benzodiazepine withdrawal, hepatic cirrhosis).
Precautions & warnings
- Agitation, anxiety, and insomnia may occur during initial stages of therapy.
- Avoid alcohol (may lower seizure threshold).
- Inform your doctor if you notice sudden mood and behavior changes or develop suicidal thoughts.
- Caution in patients with history of seizure disorders, head trauma, diabetes, alcohol abuse, bulimia/anorexia, hepatic cirrhosis, CNS tumor.
- May cause dizziness and impaired concentration; know your response before driving.
- Wait 14 days between stopping MAO inhibitor and starting bupropion.
- Caution during pregnancy and lactation.