Diamicron MR 60

• Type 2 diabetes mellitus

Gliclazide is a second generation sulfonylurea drug that has hypoglycaemic and potentially useful hematological properties. It stimulates the release of insulin from pancreatic β-cells by facilitating Ca+2 transport across the β-cell membranes and decreases hepatic glucose output.

Film-coated tablet:

• Initial dose: 40-80 mg daily
• Can be increased up to 320 mg daily in divided doses when needed
• Take before meal

Modified release preparation:

• Initial: 30 mg once daily
• Increase in increments of 30 mg up to max 120 mg daily
• Interval between doses should be at least 1 month

Children: Not used (contraindicated in juvenile-onset diabetes)

* Use as directed by the registered physician

Common Side Effects:

• Upset stomach
• Indigestion
• Hypoglycemia (low blood sugar)

Other Side Effects:

• Abdominal pain, nausea, vomiting, diarrhea, constipation
• Skin reactions (rash, redness, itching)
• Increased liver enzymes (rare)

Use in Pregnancy: Not recommended during pregnancy. If pregnant or planning pregnancy, consult your doctor.

Precautions:

• Risk of hypoglycemia may be increased in the first few weeks of treatment.
• Irregular meals, skipping meals or fasting may cause hypoglycemia.
• Avoid alcohol (increases hypoglycemia risk).
• Regular blood sugar and HbA1c monitoring required.
• Caution in severe kidney or liver disease.

Overdose: Symptoms of hypoglycemia (headache, intense hunger, nausea, vomiting, weariness, sweating, anxiety). Take sugar or sweet drinks. Unconscious patients must not be given food or drink. Seek emergency medical attention.

Storage: Store below 30°C. Keep out of reach of children.