Diascan

• Cranial and spinal resonance imaging (MRI)
• General MRI of the body
• Lesions with abnormal vascularity - in the brain (intracranial lesions), spine and associated tissues

This is a clear, colourless to slightly yellow aqueous solution containing Gadodiamide USP 287 mg/ml equivalent to 0.5 mmol/ml. For Magnetic resonance imaging, visualization of normal and pathological brain and spinal tissue depends, in part, on variations in the radiofrequency signal intensity. Gadodiamide decreases both the T1 and T2 relaxation times in tissues where it is distributed. At clinical doses, the effect is primarily on the T1 relaxation time, and produces an increase in signal intensity.

Adults and Children Dose:

• Recommended dose: 0.1 mmol/kg body weight (0.2 ml/kg body weight) up to 100 kg.
• Above 100 kg: 20 ml is usually sufficient.
• Administer as a single intravenous injection.

Adults (when brain metastases are suspected):

• 0.3 mmol/kg body weight (0.6 ml/kg body weight) up to 100 kg.
• Above 100 kg: total of 60 ml is usually sufficient.

Children (2-16 years):

• 0.2 mL/kg (0.1 mmol/kg) as a bolus intravenous injection.

* Use as directed by the registered physician

Common Side Effects (>1% and <10%):

• Sensation of warmth, coolness or local pressure or pain at injection site
• Dizziness
• Nausea
• Headache
• Perverted sense of taste or smell

Serious Side Effects: Nephrogenic systemic fibrosis (NSF), anaphylactoid reactions.

Use in Pregnancy: Pregnancy category B3. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Precautions:

• Avoid use in patients with chronic, severe kidney disease (GFR <30 mL/min/1.73m²) or acute kidney injury (risk of NSF).
• Caution in patients with known hypersensitivity or history of asthma/allergic disorders.
• Gadodiamide interferes with serum calcium measurements (do not test for 12-24 hours).
• Safety of repeated injections is not available.

Overdose: Clinical consequences have not been reported. Acute toxicity unlikely with normal renal function. Can be eliminated by hemodialysis.

Storage: Store at room temperature (below 30°C) and protected from light. Vial is intended for one patient only. Discard unused portion.