৳ 19.82/unit
Pack: ৳ 19.82
৳ 19.82/unit
Pack: ৳ 19.82
At a glance
Phytomenadione (Vitamin K1) is used for the treatment of vitamin K deficiency and bleeding caused by over-anticoagulation with warfarin. It promotes hepatic synthesis of clotting factors, normalizing the blood clotting process.
Indications
- Vitamin K deficiency (due to drugs or malabsorption)
- Over-anticoagulation with warfarin
- Prophylaxis of vitamin K deficiency bleeding in neonates
Pharmacology
Phytomenadione promotes hepatic synthesis of prothrombin and other clotting factors (VII, IX, X), restoring vitamin K activity. It accelerates the normal blood clotting process and helps prevent or treat bleeding caused by warfarin or vitamin K deficiency.
Dosage
Adult Dose:
- Oral (Vitamin K deficiency): 10-40 mg daily
- Oral (Over-anticoagulation): Up to 5 mg; depends on INR and degree of hemorrhage
- IV (Over-anticoagulation): 0.5-5 mg slow IV injection; depends on INR and degree of hemorrhage
Pediatric Dose:
- IM (Neonatal prophylaxis): 0.5-1 mg single dose; alternative: 2 mg oral, second dose 2 mg after 4-7 days
- Parenteral (Neonatal bleeding): 1 mg IV/IM/SC; further doses may be given if needed
Side effects
Common Side Effects:
- Pain, redness, or swelling at injection site
- Allergic reactions (rare)
- Flushing
- Altered taste
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use if G6PD deficiency
- Do not use as antidote for heparin
- May decrease warfarin effect; monitor INR
- Caution during pregnancy
Overdose effects
Overdose is rare; excessive doses may increase clotting risk; treatment: symptomatic; consult your doctor.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.