৳ 3.85/unit
Pack: ৳ 3.85
৳ 3.85/unit
Pack: ৳ 3.85
At a glance
Nalidixic Acid is a 4-quinolone antibiotic used for urinary tract infections and shigellosis. It inhibits bacterial DNA gyrase enzyme to prevent DNA replication.
Indications
- Urinary tract infections (caused by Proteus, Klebsiella, Enterobacter, E. coli)
- Shigellosis
Pharmacology
Nalidixic acid inhibits bacterial DNA gyrase enzyme to prevent DNA replication, resulting in bacterial cell death. It is active against gram-negative bacteria.
Dosage
Adult Dose (Oral):
- Uncomplicated lower UTI: 1 g 4 times daily for 1-2 weeks; long-term: reduce to 2 g/day
- Shigellosis: 1 g 4 times daily for 5 days
Pediatric Dose (Oral):
- >3 months: 50 mg/kg daily in 4 divided doses; long-term: 30 mg/kg daily; prophylaxis: 15 mg/kg twice daily
- Shigellosis: 15 mg/kg 4 times daily for 5 days
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Hemolysis in G6PD deficiency
- Allergic reactions (urticaria, rash, fever, arthralgia, eosinophilia)
- Myalgia, muscle weakness
- Phototoxicity
- Jaundice
- Visual disturbances
- Convulsions
Use in pregnancy
Use in Pregnancy: Nalidixic Acid may be unsafe during pregnancy (Category C); animal studies show evidence of fetal harm.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Risk-benefit consideration in first trimester of pregnancy
- Caution during breastfeeding
- Caution in renal or hepatic impairment
- Caution while driving
- Avoid alcohol
Overdose effects
Overdose: Severe bloody diarrhea; symptomatic treatment.
Storage conditions
Store below 30°C; protect from light & moisture; keep out of reach of children.