৳ 13,900/unit
Pack: ৳ 13,900
৳ 13,900/unit
Pack: ৳ 13,900
At a glance
Docetaxel is an antineoplastic medication used for the treatment of breast cancer, non-small cell lung cancer, prostate cancer, and head and neck cancers.
Indications
- Breast cancer (locally advanced or metastatic)
- Non-small cell lung cancer (NSCLC)
- Prostate cancer
- Head and neck cancers
- Gastric adenocarcinoma
Pharmacology
Docetaxel is an antineoplastic agent which acts by disrupting the microtubular network in cells that is essential for vital mitotic and interphase cellular functions. Docetaxel promotes the assembly of tubulin into stable microtubules while simultaneously inhibiting their disassembly, resulting in inhibition of mitosis.
Dosage
Adult (Breast Cancer): 60-100 mg/m² IV over 1 hour once every 3 weeks.
Adult (NSCLC, Prostate, Head/Neck, Gastric): 75 mg/m² IV over 1 hour once every 3 weeks.
Hepatic impairment: Mild-moderate: reduce dose from 100 to 75 mg/m²; Severe: avoid use.
Side effects
Common: Infections, neutropenia, anemia, febrile neutropenia, hypersensitivity, thrombocytopenia, neuropathy, dysgeusia, dyspnea, constipation, anorexia, nail disorders, fluid retention, asthenia, pain, nausea, diarrhea, vomiting, mucositis, alopecia, skin reactions, myalgia.
Use in pregnancy
Pregnancy Category D. Docetaxel is unsafe during pregnancy. There is definite evidence of risk to the developing baby.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
May affect driving ability. Higher risk of severe adverse reactions in hepatic impairment. Do not use if neutrophil count <1500 cells/mm³. Avoid during pregnancy and lactation.
Overdose effects
Overdose may cause bone marrow suppression, peripheral neurotoxicity, and mucositis. Administer G-CSF therapy and supportive measures.
Storage conditions
Store between 2°C and 25°C, protected from light. Freezing does not adversely affect the product.