Dolonac

• Pain relief

After oral intake, aceclofenac is rapidly absorbed, reaching peak plasma concentration in about 1.25 to 3 hours. It is highly protein-bound (over 99%). It is metabolized in the liver, mainly to 4'-hydroxyaceclofenac, with a smaller fraction converted to diclofenac, primarily via the CYP2C9 enzyme pathway. Its elimination half-life is approximately 4 hours, and it is excreted mainly through urine.

Adult Dose: Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly. Patients suffering from severe hepatic impairment must be monitored. Renal Dose: Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.

Common: • Vomiting • Stomach pain/epigastric pain • Nausea • Indigestion • Diarrhea • Heartburn • Loss of appetite

[CONSULT YOUR DOCTOR] Aceclofenac may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[UNSAFE] Aceclofenac may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Aceclofenac to relieve pain and inflammation. Take it with food or milk to prevent upset stomach. Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration. Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems. Inform your doctor if you have a history of heart disease or stroke. Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.

Overdose symptoms may include nausea, abdominal pain, dizziness, and in severe cases, seizures or renal impairment. Treatment is mainly symptomatic; activated charcoal may be considered if administered within 1 hour of ingestion. Intravenous diazepam may be used for seizures. Liver and kidney function should be closely monitored. Prompt medical attention is advised in case of suspected overdose.

Store below 30°C in a dry place, protected from direct sunlight. Keep out of the reach of children.