৳ 500/unit
Pack: ৳ 500
৳ 500/unit
Pack: ৳ 500
At a glance
Daunorubicin is an anti-cancer medication used for the treatment of blood cancer (leukemia). It works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Indications
- Acute Nonlymphocytic Leukemia (ANLL)
- Acute Lymphocytic Leukemia (ALL)
Pharmacology
Daunorubicin forms a stable complex with DNA and interferes with nucleic acid synthesis. It is a cell-cycle nonspecific agent, but its cytotoxic effects are mostly marked in the S-phase. It also has immunosuppressant and antibacterial effects. It inhibits topoisomerase II enzyme, which is required for DNA replication and division.
Dosage
Adult - ANLL (1st course): 100 mg/m²/day IV for 7 days (in combination with cytarabine).
Adult - ANLL (subsequent courses): 100 mg/m²/day IV for 5 days.
Adult - ALL (≥60 years): 45 mg/m² IV on days 1, 2, 3.
Child (≥2 years or >0.5 m² BSA): 25 mg/m² IV once weekly.
Side effects
Common: Nausea, vomiting, low platelet count, ulcer, abdominal pain, loss of appetite, decreased white blood cell count, hair loss, fever, anemia, fatigue, chills, diarrhea, mucosal inflammation, febrile neutropenia, stomatitis, breathing problems.
Serious: Cardiotoxicity (heart muscle damage), myelosuppression, increased infection risk, secondary leukemia.
Use in pregnancy
Pregnancy Category D. Daunorubicin is unsafe during pregnancy as there is definite evidence of risk to the developing baby. May be used in life-threatening situations if benefits outweigh risks.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Regular cardiac function monitoring is required (risk of cardiotoxicity). Monitor complete blood count, kidney, liver and heart function. Caution in elderly, children and patients with hypertension. Caution with radiation therapy. Avoid live vaccines. Both partners should avoid pregnancy.
Overdose effects
Overdose may lead to myelosuppression, cardiotoxicity, and gastrointestinal toxicity. Seek medical attention.
Storage conditions
Store as per manufacturer's instructions. Usually below 25°C, protected from light.