osudhkosh
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Company•Unimed Unihealth Pharmaceuticals Ltd.

Dostimid 60

Rx
Generic: Pyridostigmine

৳ 25/unit

Pack: ৳ 175

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At a glance

Pyridostigmine is a cholinesterase inhibitor used for myasthenia gravis, paralytic ileus, and postoperative urinary retention. It facilitates impulse transmission across the myoneural junction by inhibiting the destruction of acetylcholine.

Indications
  • Myasthenia gravis
  • Paralytic ileus
  • Postoperative urinary retention
Pharmacology

Pyridostigmine inhibits acetylcholine destruction, facilitating nerve impulse transmission across the neuromuscular junction. It has a longer duration of action and fewer GI side effects compared to neostigmine. It also has a direct cholinomimetic effect on skeletal muscles.

Dosage

Adult Dose (Oral):

  • Myasthenia gravis: 30-120 mg in divided doses; up to 0.3-1.2 g daily
  • Paralytic ileus/Postoperative urinary retention: 60-240 mg daily

Pediatric Dose (Oral):

  • Myasthenia gravis (<6 years): 30 mg initially; (6-12 years): 60 mg initially; total daily 30-360 mg (15-30 mg increments)
  • Paralytic ileus/Postoperative urinary retention: 15-60 mg daily
  • Neonates: 5-10 mg every 4 hours (30-60 min before feeding)
Side effects

Side Effects:

  • Nausea
  • Excessive salivation
  • Diarrhea
  • Blurred vision
  • Shortness of breath
  • Watery eyes
  • Abdominal pain
  • Altered urinary frequency
  • Sweating
  • Headache
  • Dizziness
  • Muscle fasciculation
  • Muscle cramps
Use in pregnancy

Use in Pregnancy: Generally considered safe; animal studies have shown low or no adverse effects; limited human studies.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if dizzy or blurred vision occurs
  • Overdose can cause extreme muscle weakness
  • Avoid alcohol (may worsen side effects)
  • Caution in renal disease, Parkinson's, asthma, stomach disorders
Overdose effects

Overdose: Muscarinic and nicotinic effects (nausea, diarrhea, abdominal cramps, muscle weakness); treatment: atropine (for muscarinic effects), symptomatic supportive care.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Pyridostigmine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.