৳ 700/unit
Pack: ৳ 700
৳ 700/unit
Pack: ৳ 700
At a glance
Doxercalciferol injection is used for the treatment of secondary hyperparathyroidism in adult patients with CKD on dialysis. It helps reduce PTH levels.
Indications
- Secondary hyperparathyroidism in CKD on dialysis
Pharmacology
Doxercalciferol is a synthetic vitamin D2 analog. It is metabolized to active 1α,25-dihydroxyvitamin D2, which binds to the vitamin D receptor and inhibits PTH synthesis and secretion.
Dosage
Adult Dose: 4 mcg IV bolus three times weekly at the end of dialysis (no more than every other day). Increase by 1-2 mcg at 8-week intervals based on PTH levels. Maximum dose: 18 mcg weekly.
Side effects
Common Side Effects:
- Infection/bacterial infection/viral infection
- Constipation
- Rhinitis
- Anemia
- Cough
- Dyspnea
- Paresthesia
- Asthenia
- Insomnia
- Hypertonia
- Angina pectoris
Use in pregnancy
Limited data available for use during pregnancy. Use only if benefits outweigh risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Hypercalcemia may occur leading to cardiac arrhythmias and seizures.
- Anaphylaxis has been reported.
- Adynamic bone disease may develop if PTH is over-suppressed.
- More frequent monitoring needed in hepatic impairment.
Overdose effects
Overdose may cause hypercalcemia, hypercalciuria and hyperphosphatemia. Not expected to be removed by dialysis.
Storage conditions
Store below 25°C, protected from light. After first use, may be stored for 3 days in refrigerator at 2°C-8°C.