৳ 1,000/unit
Pack: ৳ 1,000
৳ 1,000/unit
Pack: ৳ 1,000
At a glance
Doxorubicin Hydrochloride is used in the treatment of various types of cancer. It is an anti-cancer medication that damages the DNA of cancer cells and stops their growth and multiplication.
Indications
- Cancer
Pharmacology
Doxorubicin is a cytotoxic anthracycline antibiotic. Its cytotoxic action results from binding to DNA and inhibition of nucleic acid synthesis. It also interacts with topoisomerase II to form DNA-cleavable complexes.
Dosage
Adult Dose (IV):
- Kaposi's Sarcoma: 20 mg/m² q3Weeks
- Ovarian Cancer: 50 mg/m² q4Weeks
- Multiple Myeloma: 30 mg/m² (with bortezomib)
- Metastatic breast cancer: 60-75 mg/m² q3Weeks
Hepatic Dose: Bilirubin 1.2-3 mg/dL: 50% dose; 3.1-5 mg/dL: 25% dose; Severe impairment: Contraindicated.
Side effects
Common Side Effects (>10%):
- Alopecia
- Nausea and vomiting
Other Side Effects:
- Cardiomyopathy and arrhythmias
- Secondary malignancies
- Extravasation and tissue necrosis
- Severe myelosuppression
- Tumor lysis syndrome
Use in pregnancy
Pregnancy Category D. Can cause fetal harm. Use effective contraception during and for 6 months after treatment.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Can cause fetal harm during pregnancy.
- Discontinue if signs of cardiomyopathy develop.
- Dose reduction needed in hepatic impairment.
- Inform doctor if signs of infection (fever, sore throat, rash) occur.
Overdose effects
Overdose: 250 mg and 500 mg doses have proven fatal. May cause acute myocardial degeneration and severe myelosuppression.
Storage conditions
Store in a dry place at 2°-8°C. Protect from light and do not freeze. Keep out of reach of children.