৳ 14.28/unit
Pack: ৳ 399.84
৳ 14.28/unit
Pack: ৳ 399.84
At a glance
Drospirenone is a progestin used as an oral contraceptive in females. It prevents pregnancy primarily by suppressing ovulation. Drospirenone is a spironolactone analogue with anti-mineralocorticoid activity.
Indications
- Oral contraception
Pharmacology
Drospirenone is a progestin used to prevent pregnancy primarily by suppressing ovulation. It is a spironolactone analogue with anti-mineralocorticoid activity. Drospirenone is 95-97% bound to serum albumin and is extensively metabolized. The terminal half-life is approximately 30 hours.
Dosage
Adult Dose (Oral Contraception):
One tablet daily for 28 consecutive days: one white active tablet daily for the first 24 days and one light pink inert tablet daily for the following 4 days. Take at the same time every day.
Starting (Day 1 Start): Take the first white active tablet on the first day of menses, continue for 24 days, then take one light pink inert tablet daily for 4 days, and begin the next pack.
Side effects
Common Side Effects:
- Acne
- Metrorrhagia
- Headache
- Breast pain
- Weight increased
- Dysmenorrhea
- Nausea
- Vaginal hemorrhage
- Libido decreased
- Breast tenderness
- Menstruation irregularity
Use in pregnancy
Limited data on use during pregnancy. Discontinue if pregnancy occurs, as there is no reason to use hormonal contraceptives during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Hyperkalemia: Drospirenone has anti-mineralocorticoid activity with potential for hyperkalemia in high-risk females. Contraindicated in renal impairment, hepatic impairment, and adrenal insufficiency.
- Thromboembolic Disorders: No association between progestin-only preparations and increased risk of thromboembolism.
- Bone Loss: Drospirenone leads to decreased estradiol levels; clinically relevant bone loss unknown.
- Liver Disease: Discontinue if jaundice or liver dysfunction develops.
- Ectopic Pregnancy: Be alert to possibility in females who become pregnant or complain of lower abdominal pain.
- Hyperglycemia in Diabetes: Patients with diabetes may require additional monitoring.
- Bleeding Irregularities: Unscheduled bleeding may occur especially during first 3 months.
Overdose effects
Overdose may cause nausea, vomiting, and vaginal bleeding. No antidotes; provide symptomatic support. Monitor serum potassium and sodium, and for evidence of metabolic acidosis.
Storage conditions
Store below 30°C in a dry place, away from light. Keep out of reach of children.