৳ 280/unit
Pack: ৳ 280
৳ 280/unit
Pack: ৳ 280
At a glance
Clotrimazole 1% Topical is an antifungal cream used for the treatment of skin and nail fungal infections caused by dermatophytes, yeasts, and other fungi.
Indications
- Dermatomycoses due to dermatophytes (Trichophyton species)
- Dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Pharmacology
Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane. Because ergosterol directly promotes the growth of fungal cells in a hormone-like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth.
Dosage
Adult Dose (Topical): Apply 2-3 times daily to the infected sites and rub in. Dermatomycoses: 3-4 weeks; Candida vulvitis & balanitis: 1-2 weeks; Erythrasma & Pityriasis versicolor: approx 3 weeks; Onychomycosis: 6 months; Tinea pedis: 4 weeks.
Pediatric Dose (>2 years): Tinea cruris: 2 weeks; Tinea corporis/pedis: 4 weeks; Candidiasis/Versicolor: 4 weeks (reconsider if no improvement).
Side effects
Common Side Effects:
- Elevated serum AST (SGOT) concentrations (15%)
- Erythema (redness)
- Stinging
- Irritation
- Hypersensitivity reactions
- Contact dermatitis
- Edema
- Pruritus
- Burning
- Peeling
- Urticaria
- Skin fissures
Local Reactions: Local irritation or burning sensation may occur in very few cases; these are not considered harmful.
Use in pregnancy
Small amounts of imidazoles may be absorbed systemically following topical and vaginal administration. Should be used during pregnancy only when considered necessary by the physician. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Avoid contact with eyes.
- If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy.
- Caution during pregnancy and lactation.
- Use with caution in children under 3 years.
Overdose effects
Overdose may cause severe irritation. Consult a physician if overdose is suspected.
Storage conditions
Keep below 25°C temperature, away from light & moisture. Keep out of reach of children.