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At a glance

Eflornithine Hydrochloride Monohydrate is a cream used for the reduction of unwanted facial hair (facial hirsutism) in women. It slows down hair growth.

Indications
  • Reduction of unwanted facial hair (facial hirsutism) in women
Pharmacology

Eflornithine irreversibly binds to ornithine decarboxylase (ODC), inhibiting the anagen phase of hair production. ODC catalyzes biosynthesis of intracellular polyamines required for cell division and differentiation.

Dosage

Adult Dose (Topical): Apply twice daily, at least 8 hours apart to affected areas.

Child Dose (>12 years): Apply twice daily, at least 8 hours apart to affected areas.

Side effects

Common Side Effects:

  • Acne
  • Itching
  • Hair loss
  • Burning sensation
  • Dry skin
  • Rash
  • Paresthesia
  • Irritation
  • Folliculitis
  • Headache
  • Dizziness
  • Erythema
Use in pregnancy

Eflornithine Hydrochloride Monohydrate may be unsafe during pregnancy. Animal studies have shown harmful effects. Doctor will weigh benefits and risks.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • For external use only. Avoid contact with eyes, nose or mouth.
  • If skin irritation develops, reduce frequency to once daily temporarily. If irritation continues, discontinue treatment and consult doctor.
  • Do not apply within 5 minutes of waxing or shaving (may increase stinging/burning).
  • Do not cleanse treated area within 4 hours of application.
  • Wait at least 5 minutes after application before applying makeup or sunscreen.
  • Excessive hair growth may result from serious underlying disorders (e.g., PCOS, androgen-secreting neoplasm).
Overdose effects

Overdose is highly unlikely due to minimal cutaneous penetration. Intravenous therapeutic doses (400 mg/kg/day) may cause: hair loss, facial swelling, seizures, hearing impairment, GI disturbance, loss of appetite, headache, weakness, dizziness, anemia, thrombocytopenia and leucopenia.

Storage conditions

Store below 30°C, away from light & moisture. Keep out of reach of children.

Eflornithine Hydrochloride Monohydrate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.