৳ 7/unit
Pack: ৳ 7
৳ 7/unit
Pack: ৳ 7
At a glance
Amlodipine and Atenolol combination is used to treat hypertension (high blood pressure). It helps to lower high blood pressure and reduces the chances of future heart attack and stroke.
Indications
- Patients with essential hypertension
- Patients with angina pectoris & hypertension as co-existing diseases
- Post MI patients
- Patients with refractory angina pectoris where nitrate therapy has failed
Pharmacology
Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater effect on vascular smooth muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.
Atenolol is a cardioselective beta-blocker. The cardio-selectivity is dose-related. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS.
Dosage
Adult Dose:
- Recommended dosage is Amlodipine and Atenolol 5/25 mg tablet once daily
- If necessary, the dosage may be increased to 5/25 mg two tablets daily or as advised by the physicians
- Dosage should be individualized
- Excessive fall of BP may occur in elderly patients
- Caution in patients with COPD, thyrotoxicosis, congestive failure, vasospastic angina, hepatic & renal impairment
- Caution in diabetic patients as beta-blockers may mask tachycardia occurring with hypoglycaemia
- Withdrawal should be gradual
Renal Dose: Dose adjustment may be needed for renal impairment if creatinine clearance is less than 30 ml/min because of possible reduction in the excretion of unchanged Atenolol.
Side effects
- Sleepiness
- Headache
- Ankle swelling
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Slow heart rate
- Palpitations
- Nausea
- Edema (swelling)
- Constipation
- Tiredness
- Cold extremities
- Fatigue
- Drowsiness
- Anxiety
- Depression
Use in pregnancy
[CONSULT YOUR DOCTOR] Amlodipine + Atenolol is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby (Pregnancy Category D). However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
[UNSAFE] May cause side effects which could affect your ability to drive. May cause dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.
Get up slowly when rising from a sitting or lying position. Do not stop taking the medication suddenly without talking to your doctor as it can cause sudden increase in your blood pressure. Let your doctor know if you are pregnant or planning for pregnancy.
Caution in patients with airway obstruction (Bronchospasm). Caution in patients with severe liver damage because of prolongation of the elimination half-life of Amlodipine. Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under observation.
Overdose effects
Though not documented, hypotension and less frequently congestive cardiac failure may occur in cases of overdosage. Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal. Symptomatic treatment is suggested.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.