osudhkosh
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Company•Sun Pharmaceutical (Bangladesh) Ltd.

Encorate Chrono 300

Rx
Generic: Sodium Valproate (Valproic Acid)

৳ 9/unit

Pack: ৳ 90

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At a glance

Sodium Valproate (Valproic Acid) is an anticonvulsant and mood stabilizer used for epilepsy, bipolar disorder, and migraine prevention. It controls abnormal nerve activity by increasing GABA levels in the brain.

Indications
  • Epilepsy (complex partial seizures, absence seizures)
  • Manic episodes in bipolar disorder
  • Migraine prevention
Pharmacology

Sodium Valproate increases brain GABA levels by inhibiting GABA transaminase and enhancing GABA synthesis. GABA is an inhibitory neurotransmitter that reduces excessive nerve cell activity. It also affects sodium channels and inhibits T-type calcium channels, helping to prevent seizures.

Dosage

Adult Dose (Oral):

  • Complex partial seizures: Start 10-15 mg/kg/day; increase by 5-10 mg/kg/day weekly; max 60 mg/kg/day
  • Absence seizures: Start 15 mg/kg/day (divided q6-12hr); increase by 5-10 mg/kg/day weekly; max 60 mg/kg/day
  • Migraine prevention: 250 mg twice daily; adjust based on response; max 1000 mg/day
  • Bipolar mania: 750 mg/day in divided doses; rapid titration; max 60 mg/kg/day

Pediatric Dose:

  • ≥10 years (migraine): 250 mg twice daily; max 1000 mg/day
Side effects

Common Side Effects:

  • Nausea, vomiting
  • Weight gain, loss of appetite
  • Gum swelling, headache, sleepiness
  • Tremor, hair loss
  • Liver injury (elevated liver enzymes)
Use in pregnancy

Use in Pregnancy: Unsafe in pregnancy (Category D); definite evidence of risk to the developing baby; use only in life-threatening situations; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in liver disease or history of hepatic dysfunction
  • Unsafe in pregnancy; inform doctor if planning pregnancy
  • Avoid alcohol (increases CNS depression)
  • Monitor for suicidal thoughts/behavior
  • Regular blood tests (liver function, blood counts) required
Overdose effects

Overdose: Drowsiness, bradycardia, coma; symptomatic treatment; gastric lavage, activated charcoal; naloxone ineffective; hemodialysis limited benefit.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Sodium Valproate (Valproic Acid) — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.