Ertinib 150

Erlotinib is used in the treatment of non-small cell lung cancer and pancreatic cancer. Erlotinib should be taken on an empty stomach or should be taken one hour before or 2 hour after meal. You should continue to take it as long as your doctor advises it. The duration of treatment varies according to your needs and response to treatment. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, fatigue, rash, and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult with your doctor if it bothers you. It makes you sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. In case you develop ulceration in mouth, changes in your vision, or breathing difficulties than it is better to inform the doctor. Your doctor may advise for regular monitoring of liver function while you are taking this medicine. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. It is advised to quit smoking while taking this medicine as it can affect the working of the medicine. If you have to take an antacid or any other medicine, take it at a gap of at least 2 hours after taking the cancer medicine. Erlotinib is an anti-cancer medication. Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that modulate their growth. This medicine works by binding the chemical messenger, EGFR, hence, inhibits the cancer signaling pathways mediated by EGFR. This is how it restricts further growth of the cancer cells.

• Non-small cell lung cancer • Pancreatic cancer

Erlotinib is an epidermal growth factor receptor/human epidermal growth factor receptor type 1 (EGFR/HER1) tyrosine kinase inhibitor. It reversibly inhibits the kinase activity of EGFR, preventing autophosphorylation of tyrosine residues associated w/ the receptor, thereby inhibiting further downstream signaling and resulting in cell death.

Adult Dose: Oral Locally advanced or metastatic non-small cell lung carcinoma Adult: 150 mg once daily until disease progression or unacceptable toxicity. Reduce dose in decrements of 50 mg when necessary. Locally advanced, unresectable or metastatic pancreatic cancer Adult: As 1st-line treatment with gemcitabine: 100 mg once daily, reduce dose in decrements of 50 mg when necessary. Child Dose: Safety and efficacy not established

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Erlotinib is to be taken empty stomach.

If you miss a dose of Erlotinib, skip it and continue with your normal schedule. Do not double the dose.

Common: • Abdominal pain • Bone pain • Breathlessness • Constipation • Cough • Diarrhea • Fatigue • Fever • Infection • Muscle pain • Nausea • Rash • Stomatitis (Inflammation of the mouth) • Vomiting • Weight loss

[CONSULT YOUR DOCTOR] It is not known whether Erlotinib alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Erlotinib helps treat non-small cell lung cancer that is locally advanced, or has spread to other areas of the body. It should be taken 1 hour before or 2 hours after the meal. Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it. It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective clothing while going out. It is advisable to avoid smoking while taking this medicine, as it makes the drug ineffective and requires dose adjustment. Do not take it with medication lowering the stomach acid (such as antacids, H2 blockers including ranitidine), as it may affect the working of medicine. Inform your doctor if you develop ulceration in your mouth, changes in your vision or if you experience a worsening cough, shortness of breath, or breathing difficulties while taking this medicine. Your doctor may want you to have regular blood tests to monitor your liver function while you are having treatment with this medicine. Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Hypersensitivity.

Increased serum levels w/ potent CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, atazanavir). CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin, phenobarbital) may reduce exposure of erlotinib. Increased serum levels w/ potent inhibitors of CYP1A2 (e.g. ciprofloxacin) or capecitabine. Use w/ P-glycoprotein inhibitors (e.g. ciclosporin, verapamil) may cause altered distribution or elimination of erlotinib. Drugs that increase the pH of the GI tract (e.g. antacids, H2-receptor antagonists, or PPIs) may reduce the solubility of erlotinib thus lowering its bioavailability. Concomitant use w/ warfarin or other coumarin derivates may increase INR and bleeding events.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Erlotinib. Please consult your doctor.

[CONSULT YOUR DOCTOR] Erlotinib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Erlotinib is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Erlotinib is safe to use in patients with kidney disease. No dose adjustment of Erlotinib is recommended. Use of this medicine is not advised in patients with severe kidney disease. [CAUTION] Erlotinib should be used with caution in patients with liver disease. Dose adjustment of Erlotinib may be needed. Please consult your doctor. Limited information is available on the use of Erlotinib in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

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