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Ephedrine Hydrochloride is used to treat the low blood pressure commonly seen following spinal anesthesia. It raises blood pressure by narrowing the blood vessels of the heart. Ephedrine Hydrochloride is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Your doctor may advise for regular monitoring of blood pressure while you are taking this medicine. It may cause side effects like high blood pressure and insomnia (difficulty in sleeping). This medicine may not be suitable for some people. You must inform the doctor if you are suffering from diabetes, liver, heart or kidney disease. Also, let your doctor know about all the other medications that you are using regularly. This medicine is not usually recommended during pregnancy or breastfeeding, so always consult your doctor before taking it. Ephedrine Hydrochloride works on the blood vessels and increases the blood flow to heart and lungs, thereby improving the disease condition.

• Hypotension following spinal anesthesia

Ephedrine has both alpha- and beta-adrenergic acitivity with pronounced stimulating effects on the CNS. It increases cardiac output, induces peripheral vasoconstriction, bronchodilation, reduces intestinal tone and motility, and relaxes the bladder while contracting the sphincter muscle. It also has stimulant action on the resp center and dilates the pupil witho affecting light reflexes.

Adult Dose: Oral Acute bronchospasm Adult: As ephedrine HCl: 15-60 mg tid. Max: 150 mg/day. Diabetic neuropathic oedema 30-60 mg 3 times/day. Elderly: Initial: 50% of adult dose. Parenteral Reversal of spinal or epidural anaesthesia-induced hypotension Adult: As ephedrine HCl: 3-6 mg by slow IV inj every 3-4 min as required. Max total dose: 30 mg. Elderly: Same as adult dose. Child Dose: Oral Acute bronchospasm Child: As ephedrine HCl: 1-5 yr 15 mg tid; 6-12 yr 30 mg tid; >12 yr Same as adult dose. Parenteral Reversal of spinal or epidural anaesthesia-induced hypotension Child: 0.5 mg/kg or 16.7 mg/m2 4-6 hrly by SC or IM inj or alternatively, 0.75 mg/kg or 25 mg/m2 4 times daily by SC or IV inj.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Ephedrine Hydrochloride, please consult your doctor.

Common: • Systemic hypertension (high blood pressure) • Insomnia (difficulty in sleeping)

[SAFE] Ephedrine Hydrochloride does not usually affect your ability to drive. It is usually given as a slow injection into your veins by a doctor or healthcare professional. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Inform your doctor if you are taking or have recently taken medication to treat severe depression.

Hypersensitivity. Hypertension, thyrotoxicosis, BPH. Lactation.

Reduces antihypertensive effect of bethanidine and guanethidine. May increase clearance of dexamethasone. Increased incidence of adverse effects when used with theophylline. Potentially Fatal: Severe HTN when combined with MAOIs or withi 2 wk of discontinuance of MAOI treatment. Increased risk of arrhythmias with cardiac glycosides, quinidine or tricyclic antidepressants. Increased vasoconstriction or pressor effects with ergot alkaloids or oxytocin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Ephedrine Hydrochloride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ephedrine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ephedrine Hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Ephedrine Hydrochloride in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Ephedrine Hydrochloride in patients with liver disease. Please consult your doctor.

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