৳ 7.50/unit
Pack: ৳ 7.50
৳ 7.50/unit
Pack: ৳ 7.50
At a glance
Pheniramine Maleate is an antiallergic medication used for allergic conditions including hay fever, drug rashes, angioneurotic edema, serum sickness, allergic conjunctivitis, and food allergy. It is a competitive H1 histamine receptor antagonist that reduces itching, vasodilation, and capillary leakage.
Indications
- Allergic conjunctivitis
- Hay fever
- Drug rashes
- Angioneurotic edema
- Serum sickness
- Food allergy
- Vasomotor rhinitis and acute rhinitis
- Neurodermatitis, eczema, lichen planus, acute and chronic urticaria
- Prevention and treatment of motion sickness
- Nausea, vomiting, and vertigo due to Meniere's disease and other labyrinthine disturbances
Pharmacology
Pheniramine competes with histamine for the H1 receptor and acts as an inverse agonist. Reduction in H1 receptor activity is responsible for reduced itching, vasodilation, and capillary leakage. Inverse agonism of the H1 receptor in the CNS is responsible for sedation. Binding to H4 receptors may also contribute to reduced itching by antagonizing inflammation.
Dosage
Adult Dose (Oral):
- Allergic conditions: 15-30 mg twice or three times daily (syrup); Tablet: Up to 45 mg three times daily; Max: 3 mg/kg/day
- Motion sickness prophylaxis: First dose at least 30 minutes before travel
- Elderly: Adult dose with caution
Pediatric Dose (Oral):
- 5-10 years: Half a 45 mg tablet up to three times daily
- >10 years: 15-30 mg twice or three times daily; Max: 3 mg/kg/day
- Motion sickness prophylaxis: First dose at least 30 minutes before travel
- Under 5 years: Tablets not recommended
Side effects
Common Side Effects:
- Drowsiness/sedation (most common)
- Dizziness
- Dry mouth
- Constipation
- Nausea
- Vomiting
- Diarrhea
- Blurred vision
- Urinary retention
- Muscular weakness
Use in pregnancy
Use in Pregnancy: Pregnancy Category A; use only if strictly indicated.
Pregnancy Category: A — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness and cause drowsiness or dizziness; do not drive if these occur
- Avoid alcohol (may cause excessive drowsiness)
- Caution in prostatic hypertrophy, narrow angle glaucoma, asthma, or severe cardiovascular disease
- Anti-emetic effect may mask signs of other conditions
- Do not take on an empty stomach
Overdose effects
Overdose: Combination of CNS excitatory and depressant effects; children may experience convulsions and death. Treatment: Symptomatic and supportive; gastric lavage; diazepam or short-acting barbiturates for convulsions; vasopressors for hypotension.
Storage conditions
Store in a cool and dry place, protected from light; do not use after expiry date; keep out of reach of children.