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At a glance

Melatonin is a prescription medicine used for the treatment of insomnia and jet lag. It is a hormone secreted by the pineal gland that regulates the circadian rhythm and helps induce sleep.

Indications
  • Insomnia
  • Jet lag
  • Disrupted circadian rhythms
  • Osteoporosis
  • Sleep disturbances in menopause
  • Eating disorders
  • Sleep disturbances in ADHD
Pharmacology

Melatonin binds to MT1 and MT2 receptors to regulate neurotransmitter levels, inducing and sustaining sleep and maintaining the body's circadian rhythm.

Dosage

Adult Dose (Oral):

  • Insomnia: 3-6 mg, 1 hour before bedtime
  • Jet lag: 0.5-5 mg, 1 hour before bedtime; for eastbound/westbound travel, 4 days
  • Sarcoidosis: 20 mg/day for 4-12 months

Children (6 months-14 years): Sleep disorders: 0.30 mg/day

Side effects

Common Side Effects:

  • Headache
  • Drowsiness
  • Depression
Use in pregnancy

Use in Pregnancy: No information available on use during pregnancy; consult your doctor.

Precautions & warnings
  • Caution when driving or doing activities requiring concentration (may cause drowsiness and dizziness)
  • Do not use in autoimmune diseases
  • May increase seizure frequency in epilepsy
  • Smoking reduces melatonin effectiveness
  • Avoid alcohol
Overdose effects

No significant toxicity at high doses; symptomatic treatment.

Storage conditions

Store below 30°C, away from light; keep out of reach of children.

Melatonin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.