৳ 275/unit
Pack: ৳ 2,200
৳ 275/unit
Pack: ৳ 2,200
At a glance
Filgotinib Maleate is a JAK inhibitor used for the treatment of moderate to severe active rheumatoid arthritis and ulcerative colitis.
Indications
- Rheumatoid Arthritis: Used for moderate to severe active RA in patients who have responded inadequately to, or are intolerant to DMARDs.
- Ulcerative Colitis: Used for moderately to severely active UC in patients who had inadequate response to conventional therapy or a biologic agent.
Pharmacology
Filgotinib is an adenosine triphosphate (ATP)-competitive and reversible inhibitor of the JAK family. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane. JAK1 is important in mediating inflammatory cytokine signals. Filgotinib preferentially inhibited the activity of JAK1.
Dosage
Adult Dose (Oral):
- Rheumatoid Arthritis: 200 mg tablet once a day.
- Ulcerative Colitis: 200 mg once daily; discontinue if no therapeutic benefit after 22 weeks.
- High-risk patients (VTE, MACE, malignancy): Maintenance: 100 mg once daily; may escalate to 200 mg in case of flare.
Elderly (>=65 years, RA): 100 mg once daily; may escalate to 200 mg if insufficient control.
Elderly (UC, >=65 years): Induction: 200 mg/day; Maintenance: 100 mg/day; not recommended in patients >=75 years.
Side effects
Common Side Effects:
- Nausea
- Upper respiratory tract infection (URTI)
- Urinary tract infection (UTI)
- Dizziness
Use in pregnancy
Use in Pregnancy: Category D; animal studies showed reproductive toxicity; contraindicated during pregnancy; women of childbearing potential must use effective contraception during and for at least 1 week after cessation.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Immunosuppressive medicinal products: Combination with azathioprine, ciclosporin, tacrolimus, bDMARDs or other JAK inhibitors not recommended.
- Infections: Serious infections (pneumonia, TB, esophageal candidiasis, cryptococcosis) reported; herpes zoster requires temporary interruption.
- Malignancy: RA patients have increased risk; immunomodulatory medicinal products may increase risk.
- Fertility: Animal studies showed histopathological effects on male reproductive organs.
- Vaccinations: Live vaccines not recommended.
- Lipids: Dose-dependent increase in total cholesterol, HDL, and LDL.
- Venous thromboembolism: Consider risks and benefits in patients at increased risk of thrombosis.
Overdose effects
Overdose: Doses up to 450 mg without dose-limiting toxicity in clinical studies; in case of overdose, general supportive measures should be given.
Storage conditions
Storage: Do not store above 25 degree C. Protect from light. Keep out of reach of children.