Filgram IV/SC Injection300mcg/0.5ml

• Chemotherapy-induced Neutropenia: Reduces incidence of infection in non-myeloid malignancies receiving myelosuppressive chemotherapy.
• Acute Myeloid Leukemia: Reduces time to neutrophil recovery and duration of fever in AML patients.
• Bone Marrow Transplantation: Reduces duration of neutropenia and neutropenia-related clinical sequelae.
• Severe Chronic Neutropenia: Reduces incidence and duration of sequelae in congenital, cyclic or idiopathic neutropenia.
• HIV Infection: Prevention and treatment of persistent neutropenia in advanced HIV infection.

Adult Dose (Parenteral):

• Chemotherapy-induced neutropenia: 5 mcg/kg/day SC or IV (start not <24 hr after last antineoplastic); continue until neutrophil count normal (up to 14 days or more).
• Bone Marrow Transplantation: 10 mcg/kg/day IV infusion over 30 min or 4 hr or continuous IV or SC infusion over 24 hr.
• PBPC Mobilization: 10 mcg/kg/day SC for 4-7 days.
• Congenital Neutropenia: 12 mcg/kg/day (single or divided doses).
• HIV and Persistent Neutropenia: Initially 1 mcg/kg/day; may increase to 4 mcg/kg/day; maintenance: 300 mcg daily.

Common Side Effects:

• Bone pain
• Weakness
• Headache
• Rash
• Nausea
• Increased lactate dehydrogenase
• Vomiting
• Increased uric acid
• Oropharyngeal pain
• Hair loss
• Fatigue
• Diarrhea
• Constipation
• Decreased appetite
• Cough
• Breathing problems

Precautions:

• Filgrastim may cause fatigue which may affect driving ability.
• Do not administer within 24 hours before and after chemotherapy.
• Possibility of Filgrastim acting as a growth factor for any tumor type cannot be excluded.
• Complete blood count recommended twice per week during treatment.
• Stop and inform doctor if fever, shortness of breath, fast breathing, or trouble breathing occurs.
• Pain or redness in injection area is common; inform doctor if lump, swelling, or bruising doesn't go away.