৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Safinamide is an MAO-B inhibitor used as adjunctive therapy to levodopa/carbidopa for the treatment of off episodes in Parkinson's disease. It increases dopamine levels in the brain by blocking dopamine catabolism.
Indications
- Off episodes in Parkinson's disease (adjunctive to levodopa/carbidopa)
Pharmacology
Safinamide inhibits MAO-B enzyme, preventing dopamine breakdown, which increases dopamine levels in the brain and enhances dopaminergic activity. It helps improve motor symptoms such as tremors, rigidity, and movement difficulties in Parkinson's disease.
Dosage
Adult Dose (Oral):
- Starting: 50 mg once daily (at the same time each day)
- Maintenance: Increase to 100 mg once daily after 2 weeks (based on tolerability)
- Discontinuation: Taper 100 mg dose to 50 mg for one week before stopping
Side effects
Common Side Effects:
- Dyskinesia
- Fall
- Nausea
- Insomnia
Use in pregnancy
Use in Pregnancy: No adequate controlled studies; animal studies show adverse effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Risk of serotonin syndrome (with SSRIs, SNRIs, tricyclic antidepressants)
- May cause or exacerbate hypertension
- May cause falling asleep during daily activities
- May cause hallucinations and psychotic behavior
- May cause impulse control/compulsive behaviors
- Abrupt discontinuation may cause withdrawal hyperpyrexia and confusion
Overdose effects
No human overdose experience; in severe overdose, discontinue treatment and provide supportive care; dietary tyramine restriction for several weeks.
Storage conditions
Store below 30°C, protected from light; keep out of reach of children.