Fosfen2ml

• Control of generalized convulsive status epilepticus
• Prevention and treatment of seizures occurring during neurosurgery or head injury
• Short-term substitution for oral Phenytoin

Adult Dose (Parenteral):

• Status Epilepticus: IV infusion (100-150 mg/min), initial 15 mg/kg, then IM or IV infusion (50-100 mg/min), 4-5 mg/kg/day (1-2 divided doses).
• Neurosurgery or head injury seizure prophylaxis/treatment: IM or IV infusion (50-100 mg/min), initial 10-15 mg/kg, then 4-5 mg/kg/day.
• Temporary substitution for oral Phenytoin: IM or IV infusion (50-100 mg/min), same dose and frequency as oral Phenytoin.

Children (5+ years):

• Status Epilepticus: IV infusion (2-3 mg/kg/min), initial 15 mg/kg, then IV infusion (1-2 mg/kg/min), 4-5 mg/kg/day (1-4 divided doses).

Elderly, Hepatic & Renal Impairment: Dose reduction or slower infusion may be needed.

* Use as directed by the registered physician

Common Side Effects:

• Vomiting
• Sleepiness
• Dizziness
• Itching
• Impaired coordination
• Nystagmus (involuntary eye movement)
• Paresthesia
• Headache
• Ataxia

Serious Side Effects: Cardiovascular collapse, CNS depression, hypotension, bradycardia, heart block, asystole, ventricular fibrillation.

Precautions:

• Use with caution in patients with hypotension and severe myocardial insufficiency.
• Discontinue if a skin rash appears.
• Discontinue and do not readminister if acute hepatotoxicity occurs.
• Hemopoietic complications (thrombocytopenia, leukopenia, agranulocytosis) may occur - regular blood tests required.
• Do not abruptly discontinue antiepileptic drugs (may cause status epilepticus).
• Monitor blood glucose levels in diabetic patients.