৳ 6,314/unit
Pack: ৳ 6,314
৳ 6,314/unit
Pack: ৳ 6,314
At a glance
Dalteparin Sodium is a low molecular weight heparin analogue used to prevent harmful blood clots, particularly in acute coronary syndrome, deep vein thrombosis and pulmonary embolism.
Indications
- Venous thromboembolism
- Acute coronary syndrome (unstable angina)
- Deep vein thrombosis
- Pulmonary embolism
- Prophylaxis of venous thromboembolism during surgical procedures
- Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration
Pharmacology
Dalteparin Sodium is an antithrombotic agent, which acts mainly through its ability to potentiate the inhibition of factor Xa and thrombin by antithrombin. It has a relatively higher ability to potentiate factor Xa inhibition than to prolong aPTT.
Dosage
Adult - Venous thromboembolism: 200 U/kg daily as a single or in 2 divided doses (pregnant and high-risk patients). Max: 18,000 U/day.
Adult - Surgical VTE prophylaxis (Moderate risk): 2,500 U given 1-2 hr before surgery, then 2,500 U once daily for 5-7 days.
Adult - Surgical VTE prophylaxis (High risk): 2,500 U given 1-2 hr before and 8-12 hr after surgery, then 5,000 U daily.
Adult - Unstable angina: 120 U/kg every 12 hours for 5-8 days (with low-dose aspirin). Max: 10,000 U every 12 hours.
Adult - Haemodialysis (IV): 30-40 U/kg IV injection, then 10-15 U/kg/hr IV infusion.
Side effects
Common Side Effects:
- Injection site pain or reaction
- Allergic reactions (pruritus, rash, fever)
- Elevated AST and ALT
- Thrombocytopenia
- Bleeding
Serious Side Effects:
- Epidural or spinal haematomas (may cause permanent paralysis)
- Severe haemorrhage
Use in pregnancy
Pregnancy Category B. Dalteparin Sodium is generally considered safe during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Risk of bleeding is increased; inform your doctor if bleeding from gums, nose or wounds lasts more than 15 minutes, or blood appears in urine, stool or vomit.
- Caution is required with other anticoagulant/antiplatelet agents.
- Risk of spinal/epidural haematoma with neuraxial anaesthesia or spinal puncture.
- Do not stop taking the medication suddenly without talking to your doctor.
Overdose effects
Overdose may lead to haemorrhagic complications. Administer protamine sulfate by slow IV injection at a dose of 1 mg for every 100 anti-Xa U of dalteparin sodium given.
Storage conditions
Store between 20-25°C. Keep out of reach of children.