৳ 8.23/unit
Pack: ৳ 8.23
৳ 8.23/unit
Pack: ৳ 8.23
At a glance
Fluconazole is an antifungal medication used for the treatment of fungal infections of the mouth, throat, vagina, and other parts of the body including fingernails and toenails.
Indications
- Vaginal Candidiasis: Used for treatment of vaginal fungal infections.
- Oropharyngeal Candidiasis: Used for treatment of mouth and throat fungal infections.
- Esophageal Candidiasis: Used for treatment of esophageal fungal infections.
- Tinea Infections: Used for treatment of skin fungal infections.
- Cryptococcal Meningitis: Used for treatment of brain fungal infections.
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential component of fungal cell membrane which is responsible for the synthesis of ergosterol.
Dosage
Adult Dose (Oral/IV):
- Vaginal Candidiasis: 150 mg as a single dose.
- Oropharyngeal Candidiasis: Day 1: 200 mg, then 100 mg daily for 14 days.
- Esophageal Candidiasis: Day 1: 200 mg, then 100 mg daily for 14-30 days (up to 400 mg/day).
- Tinea Infections: 150 mg weekly for 4-6 weeks.
- Cryptococcal Meningitis: Day 1: 400 mg, then 200-400 mg daily; 6-8 weeks.
Child Dose (>1 year):
- Superficial Candidiasis: 1-2 mg/kg daily.
- Systemic Candidiasis: 3-6 mg/kg daily.
Side effects
Common Side Effects:
- Headache
- Nausea
- Rash
- Vomiting
- Abdominal discomfort
- Diarrhea
Use in pregnancy
Use in Pregnancy: Fluconazole is unsafe during pregnancy; definite evidence of risk to the developing baby; doctor may prescribe in life-threatening situations.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Fluconazole may cause dizziness or seizures which may affect driving ability.
- Prescribed to cure infection and improve symptoms.
- Do not skip doses and finish the full course of treatment.
- Use a reliable method of contraception to prevent pregnancy while taking this medicine.
- Inform doctor if yellowing of eyes or skin, dark urine, or stomach pain occurs.
- Inform doctor if severe skin rash with fever develops.
- Liver function may be checked before and during treatment.
Overdose effects
Overdose: Supportive measures and symptomatic treatment (gastric lavage if necessary); fluconazole is excreted largely in urine; hemodialysis decreases plasma levels by approximately 50%.
Storage conditions
Storage: Keep in a dry place away from light and heat. Keep out of reach of children.