৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Cimetidine is an antacid that reduces the amount of acid produced by the stomach, used for the treatment of heartburn, indigestion, peptic ulcers, and acid reflux.
Indications
- Gastroesophageal reflux disease (Acid reflux)
- Peptic ulcer disease (Gastric and duodenal ulcers)
- Heartburn and indigestion
- Zollinger-Ellison syndrome
- Pancreatic insufficiency to reduce breakdown of enzyme supplements
Pharmacology
Cimetidine competitively inhibits histamine at H2-receptors of the gastric parietal cells resulting in decreased gastric acid secretion, gastric volume and hydrogen ion concentration. It is also used in patients with pancreatic insufficiency to reduce the breakdown of pancreatic enzyme supplements.
Dosage
Adult Dose (IV):
| Indication | Dose | Schedule |
|---|---|---|
| Benign gastric and duodenal ulceration | 300 mg | 6-8 hourly (infuse over 15-20 min), max 2400 mg/day |
| Zollinger-Ellison syndrome | 300 mg | 6-8 hourly (infuse over 15-20 min), max 2400 mg/day |
Continuous infusion: 37.5 mg/hr (900 mg/day). A 150 mg IV loading dose may be given in patients requiring rapid elevation of gastric pH.
Renal Dose: CrCl <30 mL/min: 300 mg IV/IO every 12 hours; Prevention of upper GI bleeding: 25 mg/hour continuous IV infusion.
Side effects
Common Side Effects:
- Headache
- Dizziness
- Diarrhea
- Muscle pain
- Skin rash
- Tiredness
Use in pregnancy
[SAFE IF PRESCRIBED] Cimetidine is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [SAFE] Cimetidine does not usually affect your ability to drive.
- If taking once daily, take it before going to bed (very effective in controlling acid released during sleep).
- If taking with other medications (e.g., antacid), take them 2 hours before or after.
- Avoid soft drinks, citrus fruits (orange, lemon) which can irritate the stomach and increase acid secretion.
- Inform your doctor if symptoms do not improve after 2 weeks.
- Inform your doctor if you have kidney disease (dose adjustment may be needed).
- Do not stop taking the medication without talking to your doctor.
Overdose effects
Cimetidine overdose symptoms include confusion, seizures, respiratory distress, bradycardia, and ventricular arrhythmias. Treatment is symptomatic and supportive.
Storage conditions
Store in a cool and dry place, away from light and out of reach of children.