৳ 19.88/unit
Pack: ৳ 19.88
৳ 19.88/unit
Pack: ৳ 19.88
At a glance
Pethidine Hydrochloride is an opioid analgesic used for short-term (24-36 hours) relief of moderate to severe pain. It can be given via intramuscular, subcutaneous, slow intravenous bolus, intravenous infusion, and patient-controlled analgesia (PCA).
Indications
- Moderate to severe pain (short-term 24-36 hours)
- Anaesthetic adjunct
- Obstetric analgesia
- Preoperative medication
- Postoperative pain
Pharmacology
Pethidine is a phenylpiperidine derivative opioid analgesic that acts mainly as a mu-receptor agonist. It activates opioid receptors in the CNS and peripheral nervous system, reduces neurotransmitter release, and decreases postsynaptic neuron activity in the spinal cord, preventing pain transmission.
Dosage
Adult Dose (Parenteral):
- Analgesia (IM/SC): 25-100 mg every 3-4 hours
- Analgesia (slow IV): 25-50 mg every 3-4 hours
- Obstetric analgesia: 50-100 mg IM/SC; repeat after 1-3 hours if needed; max 400 mg/24 hours
- Preoperative: 25-100 mg IM/SC (1 hour before surgery)
- Postoperative: 25-100 mg IM/SC every 2-3 hours
- IV infusion: 0.3 mg/kg/hr initially
- PCA: 5-20 mg demand dose, 6-20 min lockout interval
- Elderly (>70 years): Half the normal adult dose
- Hepatic/renal impairment: Dose reduction/increased intervals
Pediatric Dose (Parenteral):
- Analgesia (IM/SC): 0.5-2 mg/kg every 4-6 hours (max 100 mg)
- Preoperative: 1-2 mg/kg IM (1 hour before surgery)
- Postoperative: 0.5-2 mg/kg IM every 2-3 hours
- Neonates: Safety not established
Side effects
Common Side Effects:
- Sleepiness
- Vomiting
- Headache
- Dizziness
- Nausea
- Constipation
- Hyperhidrosis
- Bizarre feelings
- Confusion
- Hallucinations
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects. Pregnancy Category C; may cause respiratory depression in the newborn.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness and cause drowsiness or dizziness; do not drive if these occur
- Avoid alcohol (may cause excessive drowsiness and respiratory depression)
- Caution in respiratory depression, head injury, raised intracranial pressure
- Caution in elderly, hypothyroidism, Addison's disease
- Caution in hepatic/renal impairment (risk of norpethidine toxicity)
- Do not use with or within 2 weeks of MAOIs
- Caution in cardiac arrhythmias, cor pulmonale
Overdose effects
Overdose: CNS/respiratory depression, mydriasis, bradycardia, pulmonary edema, chronic tremor, CNS excitability, seizures. Treatment: Symptomatic; naloxone can reverse opioid effects (do not use for pethidine-induced seizures).
Storage conditions
Store at room temperature; do not freeze; protect from light.