৳ 2/unit
Pack: ৳ 20
৳ 2/unit
Pack: ৳ 20
At a glance
Ramipril is an ACE inhibitor used for hypertension, congestive heart failure, and after myocardial infarction. It reduces the risk of heart attack, stroke, or cardiovascular death.
Indications
- Hypertension
- Congestive heart failure
- After acute myocardial infarction (with clinical signs of heart failure)
- Non-diabetic or diabetic glomerular nephropathy
- High cardiovascular risk (coronary heart disease, stroke, peripheral vascular disease, diabetes + risk factors)
Pharmacology
Ramipril is a prodrug that is converted to ramiprilat, which inhibits ACE, reducing angiotensin II production and causing vasodilation. It decreases aldosterone secretion and increases plasma renin activity, resulting in blood pressure reduction and decreased cardiovascular event risk.
Dosage
Adult Dose (Oral):
- Hypertension (without diuretic): 1.25-2.5 mg/day initially; 2.5-20 mg/day maintenance (single or 2 divided doses)
- Hypertension (with diuretic): 1.25 mg/day initially
- Heart failure (post-MI): 2.5 mg twice daily initially; 5 mg twice daily target
- Cardiovascular event prevention: 2.5 mg/day (1 week); 5 mg/day (next 3 weeks); 10 mg/day maintenance
- Hepatic impairment: Max 2.5 mg/day
- Renal impairment (CrCl 10-30): 1.25 mg/day initially; max 5 mg/day
- Elderly: 1.25 mg/day initially
Side effects
Common Side Effects:
- Dizziness
- Headache
- Fatigue
- Asthenia
- Dry cough
- Nausea
- Vomiting
- Diarrhea
- Hypotension
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the fetus; do not use.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect driving ability; do not drive if dizzy or drowsy
- May cause dizziness for the first few days; rise slowly
- Avoid alcohol (may exacerbate hypotension)
- Avoid potassium supplements and potassium-rich foods
- Do not use during pregnancy and lactation
Overdose effects
Overdose: Excessive peripheral vasodilation (hypotension, shock), bradycardia, electrolyte disturbances, renal failure; treatment: gastric lavage, volume and salt replacement, α1-agonists (norepinephrine, dopamine) or angiotensin II.
Storage conditions
Store at 30°C or below, protect from light; do not use after expiry date; keep out of reach of children.