৳ 6.04/unit
Pack: ৳ 302
৳ 6.04/unit
Pack: ৳ 302
At a glance
Gabapentin is an antiepileptic medicine used for neuropathic pain and seizures.
Indications
- Neuropathic Pain
- Adjunctive therapy in partial seizure and secondary generalized seizure
Pharmacology
Gabapentin is an anti-convulsant. It is a structural analog of gamma-amino-butyric-acid (GABA). All pharmacological actions following administration of Gabapentin are due to the activity of parent compound. Gabapentin binds with the alpha-2-delta subunit of voltage gated L-type Calcium channel, and inhibits branched chain amino acid transferase and probably inhibits neurotransmitter release of excitatory amino acid.
Dosage
Neuropathic Pain:
- Day 1: 300 mg single dose
- Day 2: 300 mg twice daily
- Day 3: 300 mg three times daily
- Titrate up as needed to 1800 mg/day (divided TID)
Epilepsy (12+ years):
- Effective dose: 900-1800 mg/day (3 divided doses)
- Starting dose: 300 mg three times daily
Children (3-12 years):
- Starting dose: 10-15 mg/kg/day (3 divided doses)
Renal Impairment: Dose reduction required.
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Fatigue
- Dizziness
- Ataxia
- Weight gain
- Peripheral edema
- Dry mouth
- Somnolence
- Nausea
- Vomiting
- Fever
- Nystagmus
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects. Your doctor will weigh the benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Take only as prescribed.
- Do not drive or operate machinery until you know how this medicine affects you.
- Dose reduction needed in renal impairment.
- Do not take antacids 2 hours before or after taking Gabapentin (reduces absorption).
Overdose effects
Overdose: Overdose may cause drowsiness, dizziness, ataxia. Gastric lavage and supportive care.
Storage conditions
Storage: Store below 25°C, away from light and moisture. Keep out of reach of children.