Gadosol

• MRI in brain (intracranial), spine and associated tissues
• Detection of areas with disruption of the blood brain barrier (BBB)
• Detection of abnormal vascularity

Gadoteric acid is a paramagnetic molecule that develops a magnetic moment when placed in a magnetic field. The magnetic moment enhances the relaxation rates of water protons in its vicinity, leading to an increase in signal intensity (brightness) of tissues. When placed in a magnetic field, gadoteric acid shortens the T1 and T2 relaxation times in target tissues.

Adult and Pediatric Dose (including term neonates):

• Recommended dose: 0.2 mL/kg (0.1 mmol/kg) body weight
• Administer as intravenous bolus injection (manually or by power injector)
• Flow rate for adults: approximately 2 mL/second
• Flow rate for pediatric patients: 1-2 mL/second
• May be followed by normal saline flush to ensure complete injection
• Contrast MRI can begin immediately following injection

* Use as directed by the registered physician

Common Side Effects (in clinical studies):

• Nausea
• Headache
• Injection site pain
• Injection site coldness
• Burning sensation

Serious Side Effects: Nephrogenic systemic fibrosis (NSF), anaphylactoid/anaphylactic reactions.

Use in Pregnancy: Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Precautions:

• Nephrogenic Systemic Fibrosis (NSF) has occurred in patients with impaired elimination of GBCAs.
• Higher than recommended dosing or repeat dosing appear to increase the risk.
• Hypersensitivity: Anaphylactoid/anaphylactic reactions may occur - monitor patients closely.
• Avoid use in severe kidney disease (GFR <30 mL/min/1.73m²).

Overdose: In case of overdose, Gadoteric Acid can be removed from the body by haemodialysis.

Storage: Store at 25°C. If solidification occurs due to cold, bring to room temperature (minimum 90 minutes). If solids persist, discard the vial.