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At a glance

Human Papillomavirus Quadrivalent is indicated for girls and women 9-26 years and boys and men 9-45 years for prevention of cancers, genital warts and precancerous lesions caused by HPV types 6, 11, 16 and 18.

Indications

Girls and Women (9-26 years):

  • Cervical, vulvar, vaginal and anal cancer (HPV 16 & 18)
  • Genital warts (HPV 6 & 11)
  • CIN, VIN, VaIN & AIN (HPV 6, 11, 16 & 18)

Boys and Men (9-45 years):

  • Anal, oropharyngeal and head and neck cancers (HPV 16, 18, 31, 33, 45, 52 & 58)
  • Genital warts (HPV 6 & 11)
  • AIN (HPV 6, 11, 16, 18, 31, 33, 45, 52 & 58)
Pharmacology

HPV Quadrivalent vaccine contains L1 proteins of HPV types 6, 11, 16 and 18 produced by recombinant DNA technology, which form virus-like particles (VLPs). These VLPs act as antigens and generate HPV-specific antibodies, mediating humoral immune responses against anogenital diseases.

Dosage

9 through 14 years:

  • 2-dose: 0, 6-12 months (3rd dose needed if 2nd dose given before 5 months)
  • 3-dose: 0, 2, 6 months

15 through 45 years:

  • 3-dose: 0, 2, 6 months
Side effects

Most Common (≥10%) Local and Systemic Reactions:

  • Injection-site pain (82.8-89.9%)
  • Injection-site swelling (16.9-47.8%)
  • Injection-site erythema (16.9-34.1%)
  • Headache (11.4-14.6%)
Use in pregnancy

Use in Pregnancy: Category B. Animal studies show no impaired fertility or fetal harm at recommended human dose. No adequate studies in pregnant women; use only if clearly needed.

Precautions & warnings

Precautions:

  • Observe for 15 minutes after administration to prevent syncope
  • Syncope with tonic-clonic movements has been reported
  • Immunosuppressive therapy may reduce immune response
  • Caution in severe allergic reactions to yeast or previous dose
Overdose effects

Reports of administration of higher than recommended doses; adverse event profile comparable to recommended single doses.

Storage conditions

Store at +2°C to +8°C. Do not freeze. Protect from light. Administer as soon as possible after removal from refrigeration.

Human Papillomavirus Quadrivalent — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.