৳ 80/unit
Pack: ৳ 800
৳ 80/unit
Pack: ৳ 800
At a glance
Gefapixant Citrate is a P2X3 receptor antagonist used for the treatment of refractory chronic cough.
Indications
- Refractory chronic cough
- Unexplained chronic cough
Pharmacology
Gefapixant is a selective antagonist of the P2X3 receptor. P2X3-containing receptors belong to the family of purinergic receptors and are ATP-dependent ion channels, which are also located on sensory C-fibers of the vagus nerve in the airways. C-fibers are activated in response to inflammation or chemical irritants. Under inflammatory conditions, ATP is released by mucosal cells of the respiratory tract. The binding of extracellular ATP to P2X3 receptors is recognized by C-fibers as a damage signal and is perceived as a coughing stimulus, which in turn triggers a cough reflex.
Dosage
Adult Dose:
- One 45 mg tablet orally twice daily with or without food
- If a dose is missed, skip it and take the next dose at the regular time
Severe Renal Impairment (eGFR <30 mL/min/1.73m²):
- One 45 mg tablet once daily with or without food
Elderly: No dose adjustment required (higher risk of reduced renal function)
Children (under 18 years): Safety and efficacy not established
* Use as directed by the registered physician
Side effects
Very Common (>10%):
- Dysgeusia (taste disturbance)
- Ageusia (loss of taste)
- Hypogeusia (reduced taste)
Common (1-10%):
- Upper respiratory tract infections
- Decreased appetite
- Dizziness
- Nausea
- Diarrhea
- Dry mouth
- Hypersalivation
- Epigastric pain
- Dyspepsia
Occasional: Urinary stones, bladder stones, nephrolithiasis
Use in pregnancy
Use in Pregnancy: Use during pregnancy and in women of childbearing potential who do not use contraception is not recommended.
Pregnancy Category: NA — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Use with caution in patients with known hypersensitivity to sulphonamides.
- Should not be used in patients with obstructive sleep apnea.
- May affect driving ability and use of machines (dizziness) - caution required.
Overdose effects
Overdose: Patient should be observed for adverse reactions and appropriate symptomatic treatment initiated. Gefapixant is partially removed by hemodialysis.
Storage conditions
Storage: Store below 30°C in a cool and dry place. Keep away from light. Keep out of reach of children.