Genazopt Eye Drop
1%+0.5%Rx৳ 550/unit
Pack: ৳ 550
৳ 550/unit
Pack: ৳ 550
At a glance
Brinzolamide + Timolol Eye Prep is a combination medication used in the treatment of ocular hypertension and open-angle glaucoma, particularly when monotherapy provides insufficient IOP reduction. Brinzolamide reduces aqueous humour secretion and Timolol reduces aqueous humour formation, together lowering intraocular pressure.
Indications
- Open-angle glaucoma
- Ocular hypertension - when monotherapy provides insufficient IOP reduction
Pharmacology
Brinzolamide is a carbonic anhydrase II (CA-II) inhibitor that reduces aqueous humour secretion in the ciliary processes. Timolol is a non-selective beta-adrenergic blocker that reduces aqueous humour formation and slightly increases outflow facility. These two components work through different mechanisms to reduce IOP.
Dosage
Adults: Instill 1 drop in the conjunctival sac of the affected eye(s) twice daily.
Note: Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption). Use within 4 weeks of opening.
Side effects
Common side effects: Blurred vision, eye pain, eye irritation, foreign body sensation in eyes, itching, stinging sensation, burning sensation, eye redness, taste change.
Serious (rare): Allergic reactions, bradycardia, hypotension, respiratory distress, acid-base disturbances.
Avoid driving or operating machinery until you know how this medicine affects you.
Use in pregnancy
May be unsafe during pregnancy (Category C). No adequate data on brinzolamide; animal studies have shown reproductive toxicity. Limited data on timolol eye drops show no adverse effects, but fetal bradycardia and arrhythmia have been reported. Consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May cause short-term blurring of vision after use; do not drive or operate machinery until vision is clear.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute after instillation (to reduce systemic absorption).
- Use within 4 weeks of opening the bottle.
- Remove soft contact lenses before use and wait at least 15 minutes before reinserting.
- If signs of serious reactions or hypersensitivity occur, discontinue use.
- Caution in patients with heart failure, respiratory disease (asthma, COPD), bradycardia, heart block.
Overdose effects
Overuse may increase systemic absorption, causing bradycardia, hypotension, electrolyte imbalance. Consult your doctor if symptoms occur.
Storage conditions
Do not store above 30°C. Keep away from light and moisture. Keep out of reach of children. To prevent contamination, do not touch the dropper tip to any surface. Close the bottle tightly when not in use. Do not use after 4 weeks of first opening.